Tajima C, Kawano T, Iwamasa J, Honda Y, Okamura H, Miyakita T, Koshida M
Department of Obstetrics & Gynecology, Kumamoto University Medical School.
Nihon Naibunpi Gakkai Zasshi. 1989 Nov 20;65(11):1278-85. doi: 10.1507/endocrine1927.65.11_1278.
In an effort to determine the reliability of the midluteal progesterone(P)/estradiol(E2) ratio as an index of the potential for conception, we measured the midluteal P and E2 levels in 76 infertile women who had been treated at our infertility clinic. This parameter in conception cycles was compared with that in non-conception cycles. Eighty cycles of the 76 women were classified into two groups, depending upon whether pregnancy occurred or not. Group 1 and group 2 were composed of 31 conception cycles and 49 drug-induced cycles, respectively. Midluteal concentrations of P and E2 did not show any significant differences between the two groups. The P/E2 ratios were 106.4 +/- 71.3 (mean +/- SD) and 71.5 +/- 44.16, respectively. This difference was statistically significant (p less than 0.05). Discriminant function analysis showed that the smallest probability of misclassification between the two groups decreased from 44% when using P only to 36% when using the combined P and E2. The following equation: Y = 0.0727X1 - 0.00456X2 - 0.130 was obtained (when X1 = P, X2 = E2). These results suggest that the midluteal P/E2 ratio gives clinicians the best indication of luteal function for the achievement of pregnancy.
为了确定黄体中期孕酮（P）/雌二醇（E2）比值作为受孕可能性指标的可靠性，我们测量了在我们不孕不育诊所接受治疗的76名不孕妇女的黄体中期P和E2水平。将受孕周期中的这一参数与未受孕周期中的进行比较。76名妇女的80个周期根据是否怀孕分为两组。第1组和第2组分别由31个受孕周期和49个药物诱导周期组成。两组之间黄体中期P和E2的浓度没有显示出任何显著差异。P/E2比值分别为106.4±71.3（平均值±标准差）和71.5±44.16。这种差异具有统计学意义（p＜0.05）。判别函数分析表明，两组之间错误分类的最小概率从仅使用P时的44%降至同时使用P和E2时的36%。得到以下方程：Y = 0.0727X1 - 0.00456X2 - 0.130（当X1 = P，X2 = E2时）。这些结果表明，黄体中期P/E2比值为临床医生提供了关于实现妊娠的黄体功能的最佳指标。
