Laufer N, Navot D, Schenker J G
Am J Obstet Gynecol. 1982 Aug 1;143(7):808-13. doi: 10.1016/0002-9378(82)90014-x.
Serum levels of progesterone and estradiol at early, middle, and late luteal phases were compared in nonfertile cycles in which only ovulation occurred to those in cycles in which ovulation was verified by conception. Two groups of patients were studied: 33 normal ovulatory women (12 of whom conceived) and 28 women who underwent induction of ovulation (8 of whom conceived). In each group, mean midluteal levels of progesterone and estradiol were essentially similar in nonfertile and fertile cycles. In fertile cycles, the late luteal levels of both steroids were higher than their respective midluteal values, whereas the late luteal values dropped in the nonfertile cycles. The late luteal rise in estradiol was found to be a more sensitive indicator of pregnancy than that of progesterone. The progesterone/estradiol ratio was stable during the luteal phase of fertile and nonfertile cycles. The ratio in spontaneous cycles was 34.4 +/- 4.7 and only 17.9 +/- 4.3 in induced cycles. This marked decrease suggests an impairment of steroid metabolism in women who require induction of ovulation.
在仅发生排卵的非受孕周期与通过受孕证实排卵的周期中，比较了黄体期早、中、晚期的血清孕酮和雌二醇水平。研究了两组患者：33名正常排卵女性（其中12名受孕）和28名接受促排卵治疗的女性（其中8名受孕）。在每组中，非受孕周期和受孕周期的黄体中期孕酮和雌二醇平均水平基本相似。在受孕周期中，两种类固醇的黄体晚期水平均高于各自的黄体中期值，而在非受孕周期中黄体晚期值下降。发现雌二醇的黄体晚期升高比孕酮更能敏感地指示妊娠。在受孕和非受孕周期的黄体期，孕酮/雌二醇比值稳定。自然周期中的比值为34.4±4.7，而诱导周期中仅为17.9±4.3。这种显著下降表明需要促排卵的女性存在类固醇代谢受损。
