Okła Hubert, Jasik Krzysztof P, Słodki Jan, Rozwadowska Beata, Słodki Aleksandra, Jurzak Magdalena, Pierzchała Ewa
Folia Biol (Krakow). 2014;62(4):353-9. doi: 10.3409/fb62_4.353.
The etiological agents of babesiosis are intraerythrocytic parasites of the genus Babesia, which are transmitted by ticks. The course of disease is characterized by variable severity. The risk of a complicated course of babesiosis occurs in premature infants, the elderly, splenectomized patients and other immunocompromised patients. Severe cases of this disease can lead to multiple organ dysfunction. The study focuses on the impact assessment of chronic Babesia microti invasion on the morphology and ultrastructure of rat liver. The analyzed material was comprised of liver samples collected from Wistar rats infected with a reference strain of B. microti (ATCC 30221). None of the livers collected from rats with babesiosis was enlarged. The histopathological analyses showed signs of intensive inflammatory processes, especially in the perivascular areas. The hepatic mononuclear phagocyte system was characterized by increased activity. The ultrastructral analyses confirmed disintegration of hepatocytes with vacuolization in the perivascular areas. In addition, the perisinusoidal space (space of Disse) had irregular structure. In some areas, the space of Disse was enlarged or compressed. The morphological and ultrastructural analyses of rat liver with chronic babesiosis caused by B. microti showed significant pathological changes in perivascular areas which may be the cause of hepatic dysfunction.
巴贝斯虫病的病原体是巴贝斯属的红细胞内寄生虫，通过蜱传播。疾病进程的严重程度各不相同。早产儿、老年人、脾切除患者和其他免疫功能低下的患者发生巴贝斯虫病复杂病程的风险较高。这种疾病的严重病例可导致多器官功能障碍。该研究聚焦于慢性微小巴贝斯虫感染对大鼠肝脏形态和超微结构的影响评估。分析材料包括从感染微小巴贝斯虫参考菌株（ATCC 30221）的Wistar大鼠收集的肝脏样本。从患有巴贝斯虫病的大鼠收集的肝脏均未肿大。组织病理学分析显示有强烈炎症过程的迹象，尤其是在血管周围区域。肝单核吞噬细胞系统的活性增强。超微结构分析证实肝细胞崩解，血管周围区域出现空泡化。此外，窦周间隙（狄氏间隙）结构不规则。在某些区域，狄氏间隙扩大或受压。微小巴贝斯虫引起的慢性巴贝斯虫病大鼠肝脏的形态和超微结构分析显示，血管周围区域有明显的病理变化，这可能是肝功能障碍的原因。
