Jasik Krzysztof, Kleczka Anna, Filipowska Sandra
Department of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Ostrogórska 30, 41-200 Sosnowiec, Poland.
Vet Sci. 2023 Apr 14;10(4):291. doi: 10.3390/vetsci10040291.
Babesiosis is a tick-borne disease with an increasing number of cases each year. Due to the non-specific symptoms of babesiosis, insightful analyses of the pathogenesis of babesiosis are still very important. Transmission of the disease occurs in a few ways, which makes laboratory diagnosis of piroplasmosis important. Complications associated with the infection can be tragic, especially in patients with immunological disorders. The aim of this study was the histopathological analysis of the spleen and kidney of young Wistar rats infected transplacentally with . Female rats were infected with a reference strain of (ATCC 30221), and then, birth 3-week-old males were euthanized with isoflurane. Subsequently, the material was collected at autopsy for microscopic and ultrastructural examination. Microscopic and ultrastructural analysis of the spleen and kidney showed degenerative changes within the organ parenchyma and the capsules surrounding the organ. Regenerative and reparative changes through mitotic divisions of parenchymal cells were also evident. Merozoites of were visible in the section of erythrocytes and the cells building the organ stroma. The results presented in this study proved the negative effects of on cells and tissues in rats with congenital babesiosis.
巴贝斯虫病是一种由蜱传播的疾病，每年的病例数都在增加。由于巴贝斯虫病的症状不具有特异性，因此对其发病机制进行深入分析仍然非常重要。该疾病的传播途径有几种，这使得梨形虫病的实验室诊断变得重要。与感染相关的并发症可能是致命的，尤其是在免疫功能紊乱的患者中。本研究的目的是对经胎盘感染的幼年Wistar大鼠的脾脏和肾脏进行组织病理学分析。雌性大鼠感染了（ATCC 30221）的参考菌株，然后，对出生3周龄的雄性大鼠用异氟烷进行安乐死。随后，在尸检时收集材料进行显微镜和超微结构检查。脾脏和肾脏的显微镜和超微结构分析显示，器官实质和器官周围的包膜内出现了退行性变化。通过实质细胞的有丝分裂进行的再生和修复变化也很明显。在红细胞和构成器官基质的细胞切片中可见的裂殖子。本研究结果证明了对先天性巴贝斯虫病大鼠的细胞和组织具有负面影响。
