Ma Hongzhi, Yang Fan, Lian Meng, Wang Ru, Wang Haizhou, Feng Ling, Shi Qian, Fang Jugao
Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Tumour Biol. 2015 Aug;36(8):6103-12. doi: 10.1007/s13277-015-3292-7. Epub 2015 Apr 28.
Zinc finger protein, X-linked (ZFX) is a transcriptional factor involved in many physiological processes such as embryonic stem cell survival and self-renewal. Though ZFX dysfunctions have been identified in variant human diseases and especially in cancers, its pathological roles have not been fully addressed. Here, we explored the relationship between ZFX expression and squamous cell carcinoma (SCC) of the tongue. We found that ZFX expression was significantly higher in tongue SCC tumors as compared to tumor-adjacent normal tissues. Furthermore, ZFX knockdown impeded cell proliferation, impaired colony formation ability, and lead to cell cycle arrest while induced cell apoptosis in human tongue squamous cell carcinoma cell line Tca-8113. Our results provide evidence suggesting that ZFX overexpression is associated with the development of tongue SCC and ZFX knockdown is a potential treatment for tumor suppression.
X连锁锌指蛋白（ZFX）是一种转录因子，参与许多生理过程，如胚胎干细胞的存活和自我更新。尽管在多种人类疾病尤其是癌症中已发现ZFX功能异常，但其病理作用尚未完全阐明。在此，我们探讨了ZFX表达与舌鳞状细胞癌（SCC）之间的关系。我们发现，与肿瘤邻近的正常组织相比，ZFX在舌SCC肿瘤中的表达显著更高。此外，在人舌鳞状细胞癌细胞系Tca-8113中，ZFX基因敲低可抑制细胞增殖、削弱集落形成能力、导致细胞周期停滞并诱导细胞凋亡。我们的结果提供了证据表明ZFX过表达与舌SCC的发生有关，而ZFX基因敲低是一种潜在的肿瘤抑制治疗方法。
