Ozturk Hakan
Department of Urology, School of Medicine, Sifa University, Izmir, Turkey -
Minerva Urol Nefrol. 2016 Jun;68(3):263-9. Epub 2015 Apr 28.
The aim of this paper was to review the diagnostic contributions of 18FDG-PET/CT to the restaging of renal cell carcinoma (RCC) retrospectively.
The current study included 132 patients, who were operated on between July 2007 and April 2013, for renal cell carcinoma (RCC) and received 18FDG-PET/CT scans for restaging purposes. Ninety (68.2%) of the patients were male and 42 (31.8%) were female, with a mean age of 60.7 years and standard deviation ±11.9 (range min: 28, max: 86). The patients were required to fast for 6 hours prior to scanning, and whole-body PET scanning from the skull base to the upper thighs was performed approximately 1 hour after the intravenous injection of 555 MBq of F-18 FDG. Whole body CT scanning was performed in the cranio-caudal direction. FDG-PET images were reconstructed using CT data for attenuation correction. Suspicious recurrent or metastatic lesions were confirmed by histopathology or clinical follow-up.
Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18FDG-PET/CT were 93.8%, 88.2%, 92.6%, 88.2%, and 91.6%, respectively.
18FDG-PET/CT can detect local and distant metastases with high precision in the restaging of RCC. It can play an important role in the postoperative decision-making for treatment choices, in following treatment response, and can affect decision-making.
本文旨在回顾18氟脱氧葡萄糖正电子发射断层显像/X线计算机体层成像（18FDG-PET/CT）对肾细胞癌（RCC）再分期的诊断价值。
本研究纳入了132例于2007年7月至2013年4月期间接受肾细胞癌手术治疗并接受18FDG-PET/CT扫描以进行再分期的患者。其中90例（68.2%）为男性，42例（31.8%）为女性，平均年龄60.7岁，标准差±11.9（年龄范围：最小28岁，最大86岁）。患者在扫描前需禁食6小时，静脉注射555 MBq的F-18 FDG后约1小时，进行从头颅底部至大腿上部的全身PET扫描。全身CT扫描按头足方向进行。利用CT数据对FDG-PET图像进行衰减校正重建。可疑的复发或转移病灶通过组织病理学或临床随访得以证实。
18FDG-PET/CT的敏感性、特异性、阳性预测值、阴性预测值及准确性分别为93.8%、88.2%、92.6%、88.2%和91.6%。
18FDG-PET/CT在肾细胞癌再分期中能高精度地检测局部及远处转移。它在术后治疗选择的决策、监测治疗反应以及影响决策方面可发挥重要作用。
