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本文引用的文献

1
Resolving the structure of inner ear ribbon synapses with STED microscopy.利用受激发射损耗显微镜解析内耳带状突触的结构。
Synapse. 2015 May;69(5):242-55. doi: 10.1002/syn.21812. Epub 2015 Mar 11.
2
Otoferlin deficiency in zebrafish results in defects in balance and hearing: rescue of the balance and hearing phenotype with full-length and truncated forms of mouse otoferlin.斑马鱼中 otoferlin 缺乏会导致平衡和听力缺陷：全长和截短形式的小鼠 otoferlin 对平衡和听力表型的挽救作用。
Mol Cell Biol. 2015 Mar;35(6):1043-54. doi: 10.1128/MCB.01439-14. Epub 2015 Jan 12.
3
Clarin-1 acts as a modulator of mechanotransduction activity and presynaptic ribbon assembly.Clarin-1作为机械转导活性和突触前带状物组装的调节剂。
J Cell Biol. 2014 Nov 10;207(3):375-91. doi: 10.1083/jcb.201404016. Epub 2014 Nov 3.
4
Characterization of Ribeye subunits in zebrafish hair cells reveals that exogenous Ribeye B-domain and CtBP1 localize to the basal ends of synaptic ribbons.斑马鱼毛细胞中Ribeye亚基的表征表明，外源性Ribeye B结构域和CtBP1定位于突触带的基端。
PLoS One. 2014 Sep 10;9(9):e107256. doi: 10.1371/journal.pone.0107256. eCollection 2014.
5
ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis.ArfGAP3 是光感受器突触小带复合物的一个组成部分，它与 RIBEYE 形成一个 NAD(H) 调节的、氧化还原敏感的复合物，对于内吞作用很重要。
J Neurosci. 2014 Apr 9;34(15):5245-60. doi: 10.1523/JNEUROSCI.3837-13.2014.
6
In vivo and in vitro biophysical properties of hair cells from the lateral line and inner ear of developing and adult zebrafish.发育中和成年斑马鱼侧线与内耳毛细胞的体内和体外生物物理特性
J Physiol. 2014 May 15;592(10):2041-58. doi: 10.1113/jphysiol.2013.265108. Epub 2014 Feb 24.
7
Morphological and physiological development of auditory synapses.听觉突触的形态学和生理学发育
Hear Res. 2014 May;311:3-16. doi: 10.1016/j.heares.2014.01.007. Epub 2014 Feb 5.
8
Excitability of type II cochlear afferents.II 型耳蜗传入纤维的兴奋性。
J Neurosci. 2014 Feb 5;34(6):2365-73. doi: 10.1523/JNEUROSCI.3428-13.2014.
9
The function of BDNF in the adult auditory system.BDNF 在成年听觉系统中的功能。
Neuropharmacology. 2014 Jan;76 Pt C:719-28. doi: 10.1016/j.neuropharm.2013.05.008. Epub 2013 May 18.
10
Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.突触前细胞基质蛋白 bassoon 的破坏会使毛细胞传入突触的连接带锚定、多量子释放和声音编码功能下降。
J Neurosci. 2013 Mar 6;33(10):4456-67. doi: 10.1523/JNEUROSCI.3491-12.2013.

斑马鱼毛细胞中的带状突触。

Ribbon synapses in zebrafish hair cells.

作者信息

Nicolson T

机构信息

Oregon Hearing Research Center and Vollum Institute, 3181 SW Sam Jackson Park Road, Oregon Health & Science University, Portland, OR 97239, USA.

出版信息

Hear Res. 2015 Dec;330(Pt B):170-7. doi: 10.1016/j.heares.2015.04.003. Epub 2015 Apr 25.

DOI:10.1016/j.heares.2015.04.003
PMID:25916266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4620066/
Abstract

The basic architecture and functionality of ribbon synapses of mechanosensitive hair cells are well conserved among vertebrates. Forward and reverse genetic methods in zebrafish (Danio rerio) have identified components that are critical for the development and function of ribbon synapses. This review will focus on the findings of these genetic approaches, and discuss some emergent concepts on the role of the ribbon body and calcium in synapse development, and how perturbations in synaptic vesicles lead to a loss of temporal fidelity at ribbon synapses. This article is part of a Special Issue entitled .

摘要

机械敏感毛细胞的带状突触的基本结构和功能在脊椎动物中高度保守。斑马鱼（Danio rerio）中的正向和反向遗传方法已经确定了对带状突触的发育和功能至关重要的成分。本综述将聚焦于这些遗传方法的研究结果，并讨论关于带状体和钙在突触发育中的作用的一些新出现的概念，以及突触小泡的扰动如何导致带状突触时间保真度的丧失。本文是名为《听觉突触学》特刊的一部分。