斑马鱼毛细胞中的带状突触。
Ribbon synapses in zebrafish hair cells.
作者信息
Nicolson T
机构信息
Oregon Hearing Research Center and Vollum Institute, 3181 SW Sam Jackson Park Road, Oregon Health & Science University, Portland, OR 97239, USA.
出版信息
Hear Res. 2015 Dec;330(Pt B):170-7. doi: 10.1016/j.heares.2015.04.003. Epub 2015 Apr 25.
Abstract
The basic architecture and functionality of ribbon synapses of mechanosensitive hair cells are well conserved among vertebrates. Forward and reverse genetic methods in zebrafish (Danio rerio) have identified components that are critical for the development and function of ribbon synapses. This review will focus on the findings of these genetic approaches, and discuss some emergent concepts on the role of the ribbon body and calcium in synapse development, and how perturbations in synaptic vesicles lead to a loss of temporal fidelity at ribbon synapses. This article is part of a Special Issue entitled
摘要
机械敏感毛细胞的带状突触的基本结构和功能在脊椎动物中高度保守。斑马鱼（Danio rerio）中的正向和反向遗传方法已经确定了对带状突触的发育和功能至关重要的成分。本综述将聚焦于这些遗传方法的研究结果，并讨论关于带状体和钙在突触发育中的作用的一些新出现的概念，以及突触小泡的扰动如何导致带状突触时间保真度的丧失。本文是名为《听觉突触学》特刊的一部分。
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本文引用的文献
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Otoferlin deficiency in zebrafish results in defects in balance and hearing: rescue of the balance and hearing phenotype with full-length and truncated forms of mouse otoferlin.斑马鱼中 otoferlin 缺乏会导致平衡和听力缺陷：全长和截短形式的小鼠 otoferlin 对平衡和听力表型的挽救作用。
Mol Cell Biol. 2015 Mar;35(6):1043-54. doi: 10.1128/MCB.01439-14. Epub 2015 Jan 12.
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