Freire Miguel Ángel
Instituto Multidisciplinario de Biología Vegetal (IMBIV), CONICET, Universidad Nacional de Córdoba, Facultad de Ciencias Exactas Físicas y Naturales, Edificio de Investigaciones Biológicas y Tecnológicas, CC 495, Av. Vélez Sarsfield 1611, 5000, Córdoba, Argentina,
Theory Biosci. 2015 Jun;134(1-2):47-64. doi: 10.1007/s12064-015-0209-3. Epub 2015 Apr 28.
The emergence of the first polymers played an essential role in the transition from the physicochemical to the biological domain, a perception that embodied many different world paradigms relying on only one primal polymer. However, biological complexity would have appeared with an increasing set of associated chemistries and molecular interactions of many different macromolecules. In agreement with this notion, here, the purpose is to focus specific attention on current knowledge of modern biochemistry of a set of widespread polymers likely present in the Last Universal Common Ancestor synthesized by nontemplate-driven reactions with references to their abiotic synthesis. The proposed overview describes the manner in which these polymers could have organized around two polymerization reaction cycles and integrated into a minimal organizational closure at the early stages of living systems, independently of template replication processes. This hypothesis could provide an alternative conceptual framework to evaluate a plausible scenario addressing the transition from nonliving to protocellular systems.
第一批聚合物的出现，在从物理化学领域向生物领域的转变过程中发挥了至关重要的作用，这一观点体现了许多不同的世界范式，这些范式仅依赖于一种原始聚合物。然而，随着越来越多不同大分子的相关化学性质和分子相互作用的出现，生物复杂性也随之显现。与此观点一致，本文旨在特别关注一组可能存在于最后共同祖先中的广泛聚合物的现代生物化学的当前知识，这些聚合物是通过非模板驱动反应合成的，并参考了它们的非生物合成过程。所提出的概述描述了这些聚合物围绕两个聚合反应循环进行组织并在生命系统早期阶段整合到最小组织封闭中的方式，这一过程独立于模板复制过程。这一假设可以提供一个替代的概念框架，以评估一个关于从非生命系统向原始细胞系统转变的合理设想。
