Department of Microbiology and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Med Microbiol Immunol. 2015 Aug;204(4):551-5. doi: 10.1007/s00430-015-0419-9. Epub 2015 Apr 28.
Turkey is seeing a steady rise in rates of HIV infection in the country. The number of individuals with HIV/AIDS was greater than 7000 in 2014 according to data released by the Ministry of Health, and heterosexual contacts were reported to be the main transmission routes. Istanbul has the highest number of reported cases of HIV infection. The aim of the study was to determine the prevalence of HIV-1 drug resistance in 50 heterosexual patients from Istanbul. The most prevalent subtype was found to be subtype B (56.2 %). Resistance-associated mutations were found in 14 patients with 6/14 patients being therapy-experienced and 8/14 therapy naive at the time point of analysis. With increasing number of patients who require treatment and the rapid up-scaling of the antiretroviral therapy in Turkey, HIV-1 drug resistance testing is recommended before starting treatment in order to achieve better clinical outcomes.
土耳其国内的艾滋病毒感染率呈持续上升趋势。根据卫生部公布的数据，2014 年该国艾滋病毒/艾滋病患者人数超过 7000 人，性接触被报告为主要传播途径。伊斯坦布尔报告的艾滋病毒感染病例最多。本研究旨在确定 50 名来自伊斯坦布尔的异性恋患者中 HIV-1 耐药性的流行率。最常见的亚型是 B 亚型（56.2%）。在 14 名患者中发现了耐药相关突变，其中 6 名患者为治疗经验丰富，8 名患者为分析时的治疗初治。随着需要治疗的患者数量不断增加，以及土耳其抗逆转录病毒治疗的快速扩大，建议在开始治疗前进行 HIV-1 耐药性检测，以获得更好的临床结果。
