氟代硼替吡咯正电子发射断层扫描与脑脊液生物标志物
Florbetapir positron emission tomography and cerebrospinal fluid biomarkers.
作者信息
Hake Ann, Trzepacz Paula T, Wang Shufang, Yu Peng, Case Michael, Hochstetler Helen, Witte Michael M, Degenhardt Elisabeth K, Dean Robert A
机构信息
Eli Lilly and Company, Indianapolis, IN, USA; Department of Neurology Indiana University School of Medicine, Indianapolis, IN, USA.
Eli Lilly and Company, Indianapolis, IN, USA; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Alzheimers Dement. 2015 Aug;11(8):986-93. doi: 10.1016/j.jalz.2015.03.002. Epub 2015 Apr 24.
BACKGROUND
We evaluated the relationship between florbetapir-F18 positron emission tomography (FBP PET) and cerebrospinal fluid (CSF) biomarkers.
METHODS
Alzheimer's Disease Neuroimaging Initiative-Grand Opportunity and Alzheimer's Disease Neuroimaging Initiative 2 (GO/2) healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) dementia subjects with clinical measures and CSF collected ±90 days of FBP PET data were analyzed using correlation and logistic regression.
RESULTS
In HC and MCI subjects, FBP PET anterior and posterior cingulate and composite standard uptake value ratios correlated with CSF amyloid beta (Aβ1-42) and tau/Aβ1-42 ratios. Using logistic regression, Aβ1-42, total tau (t-tau), phosphorylated tau181P (p-tau), and FBP PET composite each differentiated HC versus AD. Aβ1-42 and t-tau distinguished MCI versus AD, without additional contribution by FBP PET. Total tau and p-tau added discriminative power to FBP PET when classifying HC versus AD.
CONCLUSION
Based on cross-sectional diagnostic groups, both amyloid and tau measures distinguish healthy from demented subjects. Longitudinal analyses are needed.
背景
我们评估了氟代硼吡咯-F18正电子发射断层扫描（FBP PET）与脑脊液（CSF）生物标志物之间的关系。
方法
对阿尔茨海默病神经影像学倡议-重大机遇项目和阿尔茨海默病神经影像学倡议2（GO/2）中的健康对照（HC）、轻度认知障碍（MCI）和阿尔茨海默病（AD）痴呆受试者进行临床测量，并收集在FBP PET数据±90天内的脑脊液，采用相关性分析和逻辑回归进行分析。
结果
在HC和MCI受试者中，FBP PET前扣带回和后扣带回以及复合标准摄取值比率与脑脊液淀粉样蛋白β（Aβ1-42）和tau/Aβ1-42比率相关。使用逻辑回归分析，Aβ1-42、总tau（t-tau）、磷酸化tau181P（p-tau）和FBP PET复合物各自可区分HC与AD。Aβ1-42和t-tau可区分MCI与AD，FBP PET无额外贡献。在区分HC与AD时，总tau和p-tau增加了FBP PET的判别能力。
结论
基于横断面诊断组，淀粉样蛋白和tau测量均可区分健康受试者与痴呆受试者。需要进行纵向分析。
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