Bluemel Christina, Rubello Domenico, Colletti Patrick M, de Bree Remco, Herrmann Ken
Department of Nuclear Medicine, University Hospital of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany,
Eur J Nucl Med Mol Imaging. 2015 Aug;42(9):1469-80. doi: 10.1007/s00259-015-3049-y. Epub 2015 Apr 28.
Because imaging with ultrasound, computed tomography, magnetic resonance imaging or positron emission tomography is unreliable for preoperative lymph node staging of early-stage oral and oropharyngeal squamous cell carcinoma (OSCC), elective neck dissection has been typically performed. The targeted sampling of sentinel lymph nodes (SLN) identified by lymphoscintigraphy and detected by gamma probe has become an effective alternative for the selection of patients for regional nodal resection. With careful consideration to technique, high SLN detection rates have been reported. Advanced techniques including intraoperative handheld gamma camera imaging and freehand single photon emission computed tomography (SPECT) are expected to increase surgical confidence in these procedures. This review gives an update on SLN biopsy in patients with OSCC including clinical standards and controversial aspects.
由于超声、计算机断层扫描、磁共振成像或正电子发射断层扫描成像对于早期口腔和口咽鳞状细胞癌（OSCC）的术前淋巴结分期并不可靠，因此通常会进行选择性颈部清扫术。通过淋巴闪烁显像识别并用γ探针检测前哨淋巴结（SLN）的靶向采样已成为选择区域淋巴结切除患者的有效替代方法。在仔细考虑技术的情况下，已有高前哨淋巴结检出率的报道。包括术中手持式γ相机成像和徒手单光子发射计算机断层扫描（SPECT）在内的先进技术有望提高这些手术的手术信心。本综述介绍了OSCC患者前哨淋巴结活检的最新情况，包括临床标准和有争议的方面。
