Redaelli Marco, Mucignat-Caretta Carla, Isse Abdirisak Ahmed, Gennaro Armando, Pezzani Raffaele, Pasquale Riccardo, Pavan Valeria, Crisma Marco, Ribaudo Giovanni, Zagotto Giuseppe
Department of Molecular Medicine, University of Padova, Via Marzolo 3, 35131 Padova, Italy.
Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy.
Eur J Med Chem. 2015;96:458-66. doi: 10.1016/j.ejmech.2015.04.039. Epub 2015 Apr 21.
This work was aimed to the development of a set of new naphtoquinone derivatives that can act against glioma. The compounds were tested in order to find out their ability to inhibit the growth of glioma cells, and the results of these assays were correlated with electrochemical analysis and NMR-based reoxidation kinetic studies, suggesting that a redox mechanism underlies and may explain the observed biological behavior. In addition to a full description of the synthetic pathways, electrochemistry, NMR and single crystal X-ray diffraction data are provided.
这项工作旨在开发一组能够对抗胶质瘤的新型萘醌衍生物。对这些化合物进行了测试，以了解它们抑制胶质瘤细胞生长的能力，并且这些测定结果与电化学分析和基于核磁共振的再氧化动力学研究相关联，这表明氧化还原机制是基础，并且可能解释所观察到的生物学行为。除了对合成途径进行全面描述外，还提供了电化学、核磁共振和单晶X射线衍射数据。
