Jin Jiyang, Chen Lingshan, Zhu Zhengqiu, Wang Yaling, Chen Min, Wang Qi, Peng Xingui
Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, China. Email:
Zhonghua Yi Xue Za Zhi. 2015 Feb 17;95(7):537-40.
To explore the correlation between liver T(2)(*) value and bone mineral density (BMD) in ovariectomized (OVX) rats.
A total of 60 rats, including sham (n = 25) and OVX (n = 35) groups, underwent dual-energy X-ray absorptiometry (DEXA) and liver magnetic resonance (MR)-T(2)() mapping for lumbar vertebra BMD and T(2)() values before and after operation monthly for 4 timepoints. Also micro-computed tomography (micro-CT) and biochemical measurements were performed. The sensitivity of liver T(2)() relaxation time detecting early osteoporosis were estimated and the correlation between liver T(2)() values and BMD analyzed.
BMD of lumber vertebra in OVX group decreased compared to control group at Month 2 postoperation ((554 ± 27) mg/cm³ vs (722 ± 19) mg/cm³, P < 0.05) in synchrony with an elevation of serum ferritin concentration ((521 ± 41) ng/ml vs (441 ± 29) ng/ml, P < 0.01) and liver iron concentration ((291 ± 18) µg/g vs (237 ± 27) µg/g, P < 0.01). A significant inter-group difference of liver T(2)() was detected at Month 1 postoperation ((13.2 ± 0.7) ms vs (13.9 ± 0.4) ms, P < 0.01). Liver T(2)() was significant positively correlated with BMD in sham group (r = 0.410, P < 0.01) and OVX group (r = 0.434, P < 0.01).
Liver T(2)(*) relaxation time may a valuable detection tool of assessing pathophysiological changes of osteoporosis in early stage.
