Raymond Elizabeth G, Bracken Hillary
Gynuity Health Projects, 15 East 26th Street, Suite 801, New York, NY 10010, USA.
Contraception. 2015 Sep;92(3):212-4. doi: 10.1016/j.contraception.2015.04.008. Epub 2015 Apr 24.
To explore the potential for using last menstrual period (LMP) rather than ultrasound to establish gestational age (GA) eligibility for medical abortion.
We used the results of a recently published systematic review to identify studies with data on the number of abortion patients with GA more than 63 or 70 days by ultrasound but less than those or other specific limits by LMP. We analyzed data from these studies to estimate the proportion of women with GAs greater than 63 or 70 days by ultrasound in various subgroups of women defined by LMP.
We found three studies with relevant data. One enrolled 4257 medical abortion patients of whom 4% had GAs of >70 days by ultrasound. Of the 2681 who were certain that their LMPs began no more than 56 days prior, only 16 (0.6%) were >70 days by ultrasound. In a second much smaller study of surgical abortion patients, of whom 19% were >70 days by ultrasound, 90 women were certain that their LMPs started more than 56 days prior, and of those, 7 (7.8%) had GAs of >70 days by ultrasound. In the third study, which included surgical abortion patients with a mean GA of 61 days, at least 12% of the 138 patients with LMPs <63 days prior were >70 days by ultrasound.
The possibility that access to medical abortion can be enhanced for selected women by omitting the requirement for a screening ultrasound is promising and should be further investigated.
Gestational dating using LMP rather than ultrasound may be reasonable for selected patients before medical abortion.
探讨使用末次月经日期(LMP)而非超声来确定药物流产的孕周(GA)资格的可能性。
我们利用最近发表的一项系统评价的结果,识别那些有关于超声显示孕周超过63或70天但末次月经日期显示的孕周低于该数值或其他特定界限的流产患者数据的研究。我们分析了这些研究的数据,以估计在按末次月经日期定义的不同女性亚组中,超声显示孕周大于63或70天的女性比例。
我们找到了三项有相关数据的研究。一项研究纳入了4257例药物流产患者,其中4%的患者超声显示孕周>70天。在2681名确定其末次月经开始时间不超过56天前的患者中,只有16例(0.6%)超声显示孕周>70天。在第二项规模小得多的关于手术流产患者的研究中,19%的患者超声显示孕周>70天,90名女性确定其末次月经开始时间超过56天前,其中7例(7.8%)超声显示孕周>70天。在第三项研究中,纳入了平均孕周为61天的手术流产患者,在138例末次月经日期在63天前的患者中,至少12%的患者超声显示孕周>70天。
对于部分女性,通过省略筛查超声的要求来增加药物流产可及性的可能性是有前景的,应进一步研究。
对于部分患者,在药物流产前使用末次月经日期而非超声来确定孕周可能是合理的。