Khan Abdul Arif, Khan Zakir, Malik Abdul, Shrivastava Abhinav, Jain Sudhir K, Alshamsan Aws
Nanomedicine Research Unit, Department of Pharmaceutics, College of Pharmacy, PO Box 2457, King Saud University, Riyadh 11451, Saudi Arabia; College of Life Sciences, Cancer Hospital & Research Institute, Gwalior, MP 474009, India.
Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.
Cancer Lett. 2015 Aug 1;364(1):25-32. doi: 10.1016/j.canlet.2015.04.024. Epub 2015 Apr 24.
Recent evidences indicate potential Escherichia coli involvement in colorectal cancer etiology. Colorectal cancer cells are exclusively colonized by enteroinvasive E. coli, which regulates several factors that can affect colorectal cancer progression in susceptible individuals. Earlier, we predicted nuclear targeting of E. coli proteins and their role in colorectal cancer etiology. In this study, we predict targeting of E. coli proteins in host cell mitochondria and cytoplasm and their role in colorectal cancer. Several important biological processes are regulated in the cell cytoplasm and mitochondria, where the targeting of E. coli proteins may have several possible implications. A total of 87/561 and 315/561 E. coli proteins were found to target host cell mitochondria and cytoplasm respectively. These include several proteins with the ability to influence normal growth behavior. The current article provides an outline for E. coli protein targeting in host cells and suggests that these proteins can contribute to the colorectal cancer etiology through a variety of strategies.
最近的证据表明，大肠杆菌可能参与结直肠癌的病因。结直肠癌细胞仅被肠侵袭性大肠杆菌定殖，这种细菌调节几种可影响易感个体结直肠癌进展的因素。此前，我们预测了大肠杆菌蛋白的核靶向作用及其在结直肠癌病因中的作用。在本研究中，我们预测了大肠杆菌蛋白在宿主细胞线粒体和细胞质中的靶向作用及其在结直肠癌中的作用。细胞的细胞质和线粒体中调节着几个重要的生物学过程，大肠杆菌蛋白的靶向作用可能有多种潜在影响。分别发现共有87/561和315/561种大肠杆菌蛋白靶向宿主细胞线粒体和细胞质。这些蛋白包括几种具有影响正常生长行为能力的蛋白质。本文概述了大肠杆菌蛋白在宿主细胞中的靶向作用，并表明这些蛋白可通过多种策略促成结直肠癌的病因。
