舌鳞状细胞癌中淋巴结密度的预后意义
Prognostic significance of lymph node density in squamous cell carcinoma of the tongue.
作者信息
Ong Wilson, Zhao Runfeng, Lui Benjamin, Tan Winson, Ebrahimi Ardalan, Clark Jonathan R, Soo Khee-Chee, Tan Ngian-Chye, Tan Hiang-Khoon, Iyer N Gopalakrishna
机构信息
Division of Surgical Oncology, Singhealth/Duke-NUS Head and Neck Centre, National Cancer Centre, Singapore.
Department of Head and Neck Surgery, Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E859-66. doi: 10.1002/hed.24113. Epub 2015 Jul 15.
BACKGROUND
The prognostic significance of lymph node density in oral squamous cell carcinoma (OSCC) has been well recognized. However, its use in a specific subsite of the tongue has not been evaluated. The purpose of this study was to determine the prognostic significance of lymph node density in tongue squamous cell carcinoma (SCC).
METHODS
A retrospective analysis of 99 patients with tongue SCC who underwent primary curative resection and neck dissection was conducted. Overall survival (OS) and disease-specific survival (DSS) was used to evaluate the prognostic significance of lymph node density.
RESULTS
Lymph node density (using a cutoff of 0.06) was shown to be an independent predictor of OS and DSS. The impact of lymph node density on OS and DSS remained significant on multivariate analysis, whereas conventional nodal staging was not. An alternative staging strategy incorporating depth of invasion and lymph node density performs better than conventional TNM staging in predicting survival.
CONCLUSION
Our data suggest that lymph node density is a reliable and applicable predictor of prognosis in patients with tongue SCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E859-E866, 2016.
背景
口腔鳞状细胞癌（OSCC）中淋巴结密度的预后意义已得到充分认识。然而，其在舌部特定亚部位的应用尚未得到评估。本研究的目的是确定舌鳞状细胞癌（SCC）中淋巴结密度的预后意义。
方法
对99例行原发性根治性切除及颈部清扫术的舌SCC患者进行回顾性分析。采用总生存期（OS）和疾病特异性生存期（DSS）评估淋巴结密度的预后意义。
结果
淋巴结密度（采用0.06的临界值）被证明是OS和DSS的独立预测因素。在多因素分析中，淋巴结密度对OS和DSS的影响仍然显著，而传统的淋巴结分期则不然。在预测生存方面，一种结合浸润深度和淋巴结密度的替代分期策略比传统的TNM分期表现更好。
结论
我们的数据表明，淋巴结密度是舌SCC患者预后的可靠且适用的预测因素。©2015威利期刊公司。《头颈》38：E859 - E866，2016。
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