早期喉疣状癌放疗与手术治疗的比较：基于人群的倾向评分匹配研究。
Radiation vs surgery for early-stage laryngeal verrucous carcinoma: A population-based propensity score matched-study.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Department of Otorhinolaryngology, Osaka Police Hospital, Osaka, Japan.
出版信息
PLoS One. 2022 Oct 31;17(10):e0275271. doi: 10.1371/journal.pone.0275271. eCollection 2022.
BACKGROUND
Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma. Although VC is considered radioresistant, concrete evidence for this is absent.
METHODS
We obtained data on VC treated with surgery or radiation from the Surveillance, Epidemiology, and End Results database. Treatment selection bias was reduced by propensity score matching. Overall survival (OS) and disease-specific survival (DSS) rates were estimated using the Kaplan-Meier method. Hazard ratios (HRs) were estimated using Cox proportional hazards models.
RESULTS
Five-year OS rates in the radiation and surgery groups were 72.7% and 72.0%, respectively (P = 0.111); five-year DSS rates in the same were 86.7% and 88.4%, respectively (P = 0.234). HRs of radiation compared with surgery were 1.68 (95% confidence interval (CI), 0.96-2.95) for OS and 1.95 (95% CI, 0.69-5.53) for DSS.
CONCLUSIONS
Similar prognoses were observed in patients with VC treated with radiation and surgery. VC can be treated using radiation.
背景
疣状癌（VC）是一种罕见的鳞状细胞癌变异型。虽然 VC 被认为对放射治疗有抗性，但目前还没有具体的证据。
方法
我们从监测、流行病学和结果数据库中获得了接受手术或放射治疗的 VC 患者的数据。通过倾向评分匹配减少了治疗选择偏倚。使用 Kaplan-Meier 方法估计总生存率（OS）和疾病特异性生存率（DSS）。使用 Cox 比例风险模型估计风险比（HR）。
结果
放射治疗组和手术组的 5 年 OS 率分别为 72.7%和 72.0%（P=0.111）；同一时期的 5 年 DSS 率分别为 86.7%和 88.4%（P=0.234）。与手术相比，放射治疗的 OS 和 DSS 的 HR 分别为 1.68（95%置信区间（CI），0.96-2.95）和 1.95（95%CI，0.69-5.53）。
结论
接受放射治疗和手术治疗的 VC 患者的预后相似。可以使用放射治疗来治疗 VC。
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