Milbury Kathrin, Mallaiah Smitha, Lopez Gabriel, Liao Zhongxing, Yang Chunyi, Carmack Cindy, Chaoul Alejandro, Spelman Amy, Cohen Lorenzo
The University of Texas MD Anderson Cancer Center, Houston, TX, USA
The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Integr Cancer Ther. 2015 Sep;14(5):446-51. doi: 10.1177/1534735415583554. Epub 2015 Apr 27.
The primary purpose of this study was to establish the feasibility of a couple-based Vivekananda Yoga (VKC) intervention in lung cancer patients and caregivers. Secondly, we examined preliminary efficacy regarding quality of life (QOL) outcomes.
In this single-arm feasibility trial, patients with lung cancer undergoing radiotherapy and their caregivers participated in a 15-session VKC program that focused on the interconnectedness of the dyad. We assessed pre-and post-intervention levels of fatigue, sleep disturbances, psychological distress, overall QOL, spirituality, and relational closeness. We tracked feasibility data, and participants completed program evaluations.
We approached 28 eligible dyads of which 15 (53%) consented and 9 (60%) completed the intervention. Patients (mean age = 73 years, 63% female, all stage III) and caregivers (mean age = 62 years, 38% female, 63% spouses) completed a mean of 10 sessions and 95.5% of them rated the program as very useful. Paired t tests revealed a significant increase in patients' mental health (d = 0.84; P = .04) and a significant decrease in caregivers' sleep disturbances (d = 1.44; P = .02). Although not statistically significant, for patients, effect sizes for change scores were medium for benefit finding and small for distress (d = 0.65 and 0.37, respectively). For caregivers, medium effects were found for improvement in physical functioning (d = 0.50).
This novel supportive care program appears to be safe, feasible, acceptable, and subjectively useful for lung cancer patients and their caregivers and lends support for further study.
本研究的主要目的是确定针对肺癌患者及其照顾者开展基于夫妻的维韦卡南达瑜伽（VKC）干预措施的可行性。其次，我们考察了该干预措施在生活质量（QOL）方面的初步疗效。
在这项单臂可行性试验中，正在接受放疗的肺癌患者及其照顾者参加了一个为期15节的VKC项目，该项目侧重于夫妻双方的相互联系。我们评估了干预前后的疲劳、睡眠障碍、心理困扰、总体生活质量、精神状态和关系亲密度水平。我们跟踪了可行性数据，参与者完成了项目评估。
我们联系了28对符合条件的夫妻，其中15对（53%）同意参与，9对（60%）完成了干预。患者（平均年龄 = 73岁，63%为女性，均为III期）和照顾者（平均年龄 = 62岁，38%为女性，63%为配偶）平均完成了10节课程，其中95.5%的人将该项目评为非常有用。配对t检验显示，患者的心理健康状况有显著改善（d = 0.84；P = .04），照顾者的睡眠障碍有显著减少（d = 1.44；P = .02）。虽然未达到统计学显著性，但对于患者而言，获益发现的变化得分效应量为中等，困扰的效应量为小（分别为d = 0.65和0.37）。对于照顾者而言，身体功能改善的效应量为中等（d = 0.50）。
这项新颖的支持性护理项目似乎对肺癌患者及其照顾者是安全、可行、可接受且主观上有用的，为进一步研究提供了支持。
