通过脱羧生成的二氟卡宾进行的二氟甲基化和偕二氟环丙烯化反应。
Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation.
作者信息
Deng Xiao-Yun, Lin Jin-Hong, Zheng Jian, Xiao Ji-Chang
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
出版信息
Chem Commun (Camb). 2015 May 25;51(42):8805-8. doi: 10.1039/c5cc02736e.
PMID:25918009
Abstract
Difluoromethylation of the activated X-H bond (X = N, O and S) and aliphatic thiols, and gem-difluorocyclopropenation of alkynes with difluorocarbene generated in situ from difluoromethylene phosphobetaine (Ph3P(+)CF2CO2(-)) by decarboxylation occurred smoothly without the presence of any base or other additives.
摘要
活化的X-H键（X = N、O和S）以及脂肪族硫醇的二氟甲基化，以及通过二氟亚甲基膦甜菜碱（Ph3P(+)CF2CO2(-)）脱羧原位生成的二氟卡宾与炔烃的偕二氟环丙烷化反应，在没有任何碱或其他添加剂的情况下顺利发生。
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