一种新的芳香族二氟甲基化方法：铜催化的芳基碘交叉偶联和脱羧序列。
A new method for aromatic difluoromethylation: copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides.
机构信息
Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan.
出版信息
Org Lett. 2011 Oct 21;13(20):5560-3. doi: 10.1021/ol202289z. Epub 2011 Sep 28.
PMID:21955064
Abstract
A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with α-silyldifluoroacetates upon treatment with copper catalyst in DMSO or DME to give the corresponding aryldifluoroacetates in moderate to good yields. The subsequent hydrolysis of aryldifluoroacetates and KF-promoted decarboxylation afforded a variety of difluoromethyl aromatics.
摘要
本文描述了一种新的芳香族二氟甲基化方法。芳基碘化物与α-硅基二氟乙酸酯在 DMSO 或 DME 中经铜催化剂处理，以中等至良好的收率得到相应的芳基二氟乙酸酯。随后对芳基二氟乙酸酯进行水解和 KF 促进的脱羧反应，可得到多种二氟甲基芳烃。
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