Skorvanek Matej, Rosenberger Jaroslav, Minar Michal, Grofik Milan, Han Vladimir, Groothoff Johan W, Valkovic Peter, Gdovinova Zuzana, van Dijk Jitse P
Dept. of Neurology, Faculty of Medicine, Safarik University, Kosice, Slovak Republic; Dept. of Neurology, University Hospital of L. Pasteur, Kosice, Slovak Republic; Graduate School Kosice Institute for Society and Health, Safarik University, Kosice, Slovak Republic.
Graduate School Kosice Institute for Society and Health, Safarik University, Kosice, Slovak Republic.
J Neurol Sci. 2015;353(1-2):87-91. doi: 10.1016/j.jns.2015.04.013. Epub 2015 Apr 17.
The Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a newly developed comprehensive tool to assess Parkinson's disease (PD), which covers a wider range of non-motor PD manifestations than the original UPDRS scale. The aim of this study was to assess the relationship between the MDS-UPDRS and Quality of Life (QoL) and to analyze the relationship between individual MDS-UPDRS non-motor items and QoL. A total of 291 PD patients were examined in a multicenter Slovak study. Patients were assessed by the MDS-UPDRS, HY scale and PDQ39. Data were analyzed using the multiple regression analyses. The mean participant age was 68.0 ± 9.0 years, 53.5% were men, mean disease duration was 8.3 ± 5.3 years and mean HY was 2.7 ± 1.0. In a multiple regression analysis model the PDQ39 summary index was related to MDS-UPDRS parts II, I and IV respectively, but not to part III. Individual MDS-UPDRS non-motor items related to the PDQ39 summary index in the summary group and in the non-fluctuating patients subgroup were pain, fatigue and features of dopamine dysregulation syndrome (DDS). In the fluctuating PD patient subgroup, PDQ39 was related to pain and Depressed mood items. Other MDS-UPDRS non-motor items e.g. Anxious mood, Apathy, Cognitive impairment, Hallucinations and psychosis, Sleep problems, Daytime sleepiness and Urinary problems were related to some PDQ39 domains. The overall burden of NMS in PD is more important in terms of QoL than motor symptoms. Individual MDS-UPDRS non-motor items related to worse QoL are especially pain and other sensations, fatigue and features of DDS.
运动障碍学会统一帕金森病评定量表（MDS - UPDRS）是一种新开发的用于评估帕金森病（PD）的综合工具，与原始的UPDRS量表相比，它涵盖了更广泛的非运动性PD表现。本研究的目的是评估MDS - UPDRS与生活质量（QoL）之间的关系，并分析MDS - UPDRS各个非运动项目与QoL之间的关系。在一项多中心斯洛伐克研究中，共对291例PD患者进行了检查。患者接受了MDS - UPDRS、Hoehn - Yahr（HY）量表和PDQ39评估。使用多元回归分析对数据进行分析。参与者的平均年龄为68.0±9.0岁，男性占53.5%，平均病程为8.3±5.3年，平均HY评分为2.7±1.0。在多元回归分析模型中，PDQ39总结指数分别与MDS - UPDRS的第二部分、第一部分和第四部分相关，但与第三部分无关。在总结组和非波动患者亚组中，与PDQ39总结指数相关的MDS - UPDRS非运动项目有疼痛、疲劳和多巴胺调节障碍综合征（DDS）的特征。在波动的PD患者亚组中，PDQ39与疼痛和情绪低落项目相关。其他MDS - UPDRS非运动项目，如焦虑情绪、淡漠、认知障碍、幻觉和精神病、睡眠问题、日间嗜睡和泌尿系统问题，与某些PDQ39领域相关。就QoL而言，PD中非运动症状的总体负担比运动症状更重要。与较差QoL相关的MDS - UPDRS非运动项目尤其包括疼痛和其他感觉、疲劳以及DDS的特征。
