Yin Zundong, Wang Xuxia, Li Li, Li Hui, Zhang Xiaoshu, Li Junhong, Ning Guijun, Li Fengqin, Liang Xuefeng, Gao Li, Liang Xiaofeng, Li Yixing
National Immunization Programme, Chinese Center for Disease Control and Prevention, Beijing, China; Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China.
National Immunization Programme, Chinese Center for Disease Control and Prevention, Beijing, China; Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China
Am J Trop Med Hyg. 2015 Jun;92(6):1125-9. doi: 10.4269/ajtmh.14-0148. Epub 2015 Apr 27.
We conducted a follow-up survey for 55 Japanese encephalitis (JE) cases 1-2 years after hospital discharge in Gansu province, China. Community-, education-, and gender-matched healthy individuals without history of neurologic disease were selected as the comparison group. All subjects received neurological examination, intelligence quotient (IQ) measurement, adaptive behavior measurement, and Wechsler memory scale (WMS) assessment. We found 43.6% JE cases had at least one nervous system sequelae compared with 3.6% healthy individuals. Among JE cases, 22.4% had subnormal IQ, 18.4% subnormal verbal IQ (VIQ), 20.4% subnormal performance IQ (PIQ), and 78.4% had subnormal memory quotient (MQ). Among healthy individuals, 2.0% had subnormal IQ, VIQ, or PIQ and 8.1% had subnormal MQ. Among adult JE cases, 47.8% and 39.1% had adaptive behavior impairments and intellectual disability, respectively, compared with 18.8% and 9.7% among young cases, respectively. The results showed both adult and young surviving JE cases had significant neurological sequelae and mental disability 1-2 years after discharged.
我们在中国甘肃省对55例日本脑炎（JE）患者出院后1至2年进行了随访调查。选择社区、教育程度和性别匹配且无神经系统疾病史的健康个体作为对照组。所有受试者均接受了神经系统检查、智商（IQ）测量、适应性行为测量以及韦氏记忆量表（WMS）评估。我们发现，43.6%的JE患者至少有1种神经系统后遗症，而健康个体的这一比例为3.6%。在JE患者中，22.4%的患者智商低于正常水平，18.4%的患者言语智商（VIQ）低于正常水平，20.4%的患者操作智商（PIQ）低于正常水平，78.4%的患者记忆商（MQ）低于正常水平。在健康个体中，2.0%的个体智商、VIQ或PIQ低于正常水平，8.1%的个体MQ低于正常水平。在成年JE患者中，分别有47.8%和39.1%的患者存在适应性行为障碍和智力残疾，而在年轻患者中，这两个比例分别为18.8%和9.7%。结果显示，成年和年轻的JE存活患者在出院后1至2年都有明显的神经系统后遗症和精神残疾。
