Cody Samantha Gabrielle, Adam Awadalkareem, Siniavin Andrei, Kang Sam S, Wang Tian
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.
Pathogens. 2024 Dec 31;14(1):22. doi: 10.3390/pathogens14010022.
Flaviviruses, a group of single-stranded RNA viruses spread by mosquitoes or ticks, include several significant neurotropic viruses, such as West Nile virus (WNV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV), and Zika virus (ZIKV). These viruses can cause a range of neurological diseases during acute infection, from mild, flu-like symptoms to severe and fatal encephalitis. A total of 20-50% of patients who recovered from acute flavivirus infections experienced long-term cognitive issues. Here, we discuss these major neurotropic flaviviruses-induced clinical diseases in humans and the recent findings in animal models and provide insights into the underlying disease mechanisms.
黄病毒是一类通过蚊子或蜱传播的单链RNA病毒，包括几种重要的嗜神经病毒，如西尼罗河病毒（WNV）、日本脑炎病毒（JEV）、蜱传脑炎病毒（TBEV）和寨卡病毒（ZIKV）。这些病毒在急性感染期间可引起一系列神经系统疾病，从轻微的流感样症状到严重的致命性脑炎。在从急性黄病毒感染中康复的患者中，共有20%至50%经历了长期认知问题。在此，我们讨论这些主要嗜神经黄病毒在人类中引起的临床疾病以及动物模型中的最新发现，并深入了解潜在的疾病机制。
