Zapata-Estrella Hiatzy E, Sánchez-Pardenilla Azeret D M, García-Sosa Karlina, Escalante-Erosa Fabiola, de Campos-Buzzi Fátima, Meira-Quintão Nara Lins, Cechinel-Filho Valdir, Peña-Rodríguez Luis M
Nat Prod Commun. 2014 Sep;9(9):1319-21.
The bioassay-guided purification of the ethanol extracts of Acmella pilosa and Cnidoscolus souzae, two plants of the native flora of the Yucatan Peninsula used in traditional medicine to treat inflammation and pain, resulted in the identification of rosmarinic acid (1) and caffeic acid (2) as the bioactive metabolites from A. pilosa, and of 7-deoxynimbidiol (4) as the major bioactive metabolite from C. souzae. Metabolites 1, 2, and 4 proved to be responsible for the antioxidant activity originally detected in the corresponding organic crude extracts; 7-deoxynimbidiol (4) showed good analgesic and anti-inflammatory activities, inhibiting the pain induced by PGE2 and reducing the edema induced by carrageenan, respectively.
对来自尤卡坦半岛本地植物群的两种植物——针状金钮扣和苏扎大戟的乙醇提取物进行生物测定指导下的纯化，结果鉴定出迷迭香酸（1）和咖啡酸（2）是针状金钮扣的生物活性代谢物，7-脱氧宁比二醇（4）是苏扎大戟的主要生物活性代谢物。代谢物1、2和4被证明是相应有机粗提物中最初检测到的抗氧化活性的原因；7-脱氧宁比二醇（4）显示出良好的镇痛和抗炎活性，分别抑制前列腺素E2诱导的疼痛和减轻角叉菜胶诱导的水肿。
