Ventoulis Ioannis, Mantziari Lilian, Mouratoglou Sophia-Anastasia, Kamperidis Vasileios, Giannakoulas George, Ziakas Antonios, Tsalikakis Dimitris, Giamouzis Gregory, Hitoglou-Makedou Areti, Karvounis Haralambos
1st Department of Cardiology, AHEPA University Hospital , Thessaloniki , Greece.
Scand Cardiovasc J. 2015 Aug;49(4):213-9. doi: 10.3109/14017431.2015.1043141. Epub 2015 May 11.
Neutrophil gelatinase-associated lipocalin (NGAL) and ST2 receptor, a member of the interleukin-1 receptor family, are novel biomarkers with a potential role in the diagnosis and risk stratification of patients with chronic heart failure (CHF). There is however scarce data on their relation with clinical characteristics and cardiac function in patients with CHF.
Consecutive ambulatory patients with CHF were studied. All patients underwent clinical and echocardiographic assessment, and blood samples were collected for the estimation of ST2 and NGAL serum levels during the same assessment.
A total of 76 patients (79% male, mean age: 63 ± 14 years), with CHF and left ventricular ejection fraction of 28 ± 7% were included. Median NGAL was 0.16 (0.09-0.275) mg/L and median ST2 was 0.0125 (0.0071-0.0176) mg/L. No association between NGAL and ST2 was observed. Multivariate analysis revealed tissue Doppler-derived right ventricular systolic velocity as an independent predictor of ST2, and the duration of HF and serum creatinine levels as independent predictors of NGAL.
NGAL levels depend on the renal function and the duration of HF, while ST2 levels are affected by the right but not the left ventricular function and show no association with clinical indices of HF.
中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和白细胞介素-1受体家族成员ST2受体是新型生物标志物，在慢性心力衰竭（CHF）患者的诊断和风险分层中可能发挥作用。然而，关于它们与CHF患者临床特征和心功能关系的数据却很少。
对连续性门诊CHF患者进行研究。所有患者均接受临床和超声心动图评估，并在同一评估期间采集血样以测定ST2和NGAL血清水平。
共纳入76例CHF患者（男性占79%，平均年龄：63±14岁），左心室射血分数为28±7%。NGAL中位数为0.16（0.09 - 0.275）mg/L，ST2中位数为0.0125（0.0071 - 0.0176）mg/L。未观察到NGAL与ST2之间存在关联。多变量分析显示，组织多普勒测定的右心室收缩速度是ST2的独立预测因子，心力衰竭持续时间和血清肌酐水平是NGAL的独立预测因子。
NGAL水平取决于肾功能和心力衰竭持续时间，而ST2水平受右心室功能而非左心室功能影响，且与心力衰竭临床指标无关联。
