Shih I-Lun, Yen Ruoh-Fang, Chen Chi-An, Chen Bang-Bin, Wei Shwu-Yuan, Chang Wen-Chun, Sheu Bor-Ching, Cheng Wen-Fang, Tseng Yao-Hui, Chen Xin-Jia, Chen Chi-Hau, Wei Lin-Hung, Chiang Ying-Cheng, Torng Pao-Ling, Yen Men-Luh, Shih Tiffany Ting-Fang
Department of Medical Imaging and Radiology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
J Magn Reson Imaging. 2015 Dec;42(6):1723-32. doi: 10.1002/jmri.24932. Epub 2015 Apr 27.
To evaluate the correlation between maximum standardized uptake value (SUVmax ) and minimum apparent diffusion coefficient (ADCmin ) of endometrial cancer derived from an integrated positron emission tomography / magnetic resonance (PET/MR) system and to determine their correlation with pathological prognostic factors.
This prospective study was approved by the Institutional Review Board of the hospital, and informed consent was obtained. Between April and December 2014, 47 consecutive patients with endometrial cancer were enrolled and underwent simultaneous PET/MR examinations before surgery. Thirty-six patients with measurable tumors on PET/MR were included for image analysis. Pearson's correlation coefficient was used to evaluate the correlation between SUVmax and ADCmin of the tumors. The Mann-Whitney U-test was utilized to evaluate relationships between these two imaging biomarkers and pathological prognostic factors.
The mean SUVmax and ADCmin were 14.7 ± 7.1 and 0.48 ± 0.13 × 10(-3) mm(2) /s, respectively. A significant inverse correlation was found between SUVmax and ADCmin (r = -0.53; P = 0.001). SUVmax was significantly higher in tumors with advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis (P < 0.05). ADCmin was lower in tumors with higher grade, advanced stage, and cervical invasion (P < 0.05). The ratio of SUVmax to ADCmin was higher in tumors with higher grade, advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis (P < 0.05).
SUVmax and ADCmin of endometrial cancer derived from integrated PET/MR are inversely correlated and are associated with pathological prognostic factors.
评估正电子发射断层扫描/磁共振成像（PET/MR）一体机所测得的子宫内膜癌最大标准化摄取值（SUVmax）与最小表观扩散系数（ADCmin）之间的相关性，并确定它们与病理预后因素的相关性。
本前瞻性研究经医院机构审查委员会批准，并获得了知情同意。2014年4月至12月期间，连续纳入47例子宫内膜癌患者，术前均接受了PET/MR同步检查。对PET/MR上有可测量肿瘤的36例患者进行图像分析。采用Pearson相关系数评估肿瘤SUVmax与ADCmin之间的相关性。利用Mann-Whitney U检验评估这两种影像生物标志物与病理预后因素之间的关系。
SUVmax和ADCmin的平均值分别为14.7±7.1和0.48±0.13×10(-3) mm(2)/s。SUVmax与ADCmin之间存在显著的负相关（r = -0.53；P = 0.001）。在晚期、肌层浸润深、宫颈浸润、脉管间隙受累和淋巴结转移的肿瘤中，SUVmax显著更高（P < 0.05）。在高分级、晚期和宫颈浸润的肿瘤中，ADCmin更低（P < 0.05）。在高分级、晚期、肌层浸润深、宫颈浸润、脉管间隙受累和淋巴结转移的肿瘤中，SUVmax与ADCmin的比值更高（P < 0.05）。
PET/MR一体机所测得的子宫内膜癌SUVmax与ADCmin呈负相关，并与病理预后因素相关。
