Rain Carmen, Rada Gabriel
Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Lira 63, Santiago Centro, Chile. Email:
Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; GRADE working group; The Cochrane Collaboration; Fundación Epistemonikos.
Medwave. 2015 Jun 5;15 Suppl 1:e6148. doi: 10.5867/medwave.2015.6149.
This Living FRISBEE (Living FRIendly Summary of the Body of Evidence using Epistemonikos) is an update of the summary published in April 2015, based on a new systematic review published in May 2015. The main clinical guidelines recommend the use of digitalis for chronic heart failure when moderate to severe symptoms persist after standard therapy, even though there is controversy about its efficacy and security. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified four systematic reviews including 13 randomized trials. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded the use of digitalis for chronic heart failure probably leads to little or no decrease in mortality, but they might reduce hospitalizations and clinical deterioration. However, the certainty of the evidence is low.
这份《活页飞盘》（使用Epistemonikos的循证医学友好总结）是基于2015年5月发表的一项新的系统评价，对2015年4月发表的总结进行的更新。主要临床指南建议，在标准治疗后中度至重度症状仍持续存在时，使用洋地黄治疗慢性心力衰竭，尽管其疗效和安全性存在争议。通过检索由筛选30个数据库维护的Epistemonikos数据库，我们确定了四项系统评价，包括13项随机试验。我们使用荟萃分析合并证据，并按照GRADE方法生成了结果总结表。我们得出结论，使用洋地黄治疗慢性心力衰竭可能对死亡率几乎没有降低或没有降低，但可能会减少住院次数和临床恶化。然而，证据的确定性较低。
