抗生素预防性治疗对急性胰腺炎有益吗？——首次更新。

Is antibiotic prophylaxis beneficial in acute pancreatitis?--First update.

作者信息

Rada Gabriel, Peña José

机构信息

Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile; GRADE working group; The Cochrane Collaboration; Fundación Epistemonikos. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile Lira 63, Santiago Centro, Chile. Email:

出版信息

Medwave. 2015 Apr 23;15(3):e6125. doi: 10.5867/medwave.2015.03.6125.

DOI:10.5867/medwave.2015.03.6125

PMID:25938428

Abstract

This Living FRISBEE (Living FRIendly Summary of the Body of Evidence using Epistemonikos) is an update of the summary published in August 2014, based on two systematic reviews appeared in January and February 2015. There is controversy about the effects of prophylactic antibiotics in acute pancreatitis. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified 18 systematic reviews including 19 randomised studies overall. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded that prophylactic antibiotics may reduce mortality and length of hospitalization in patients with acute pancreatitis, but the certainty of the evidence is low. The probability that future evidence change what we know is high.

摘要

这份《活体飞盘》（使用Epistemonikos的循证医学友好证据总结）是基于2015年1月和2月发表的两项系统评价，对2014年8月发表的总结进行的更新。关于预防性抗生素在急性胰腺炎中的作用存在争议。通过在由筛选30个数据库维护的Epistemonikos数据库中进行检索，我们共识别出18项系统评价，其中包括19项随机研究。我们使用荟萃分析合并证据，并按照GRADE方法生成了研究结果总结。我们得出结论，预防性抗生素可能会降低急性胰腺炎患者的死亡率和住院时间，但证据的确定性较低。未来证据改变我们现有认知的可能性很大。