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采用波分复用技术的多模态非接触光声与光学相干断层扫描成像

Multimodal noncontact photoacoustic and optical coherence tomography imaging using wavelength-division multiplexing.

作者信息

Berer Thomas, Leiss-Holzinger Elisabeth, Hochreiner Armin, Bauer-Marschallinger Johannes, Buchsbaum Andreas

出版信息

J Biomed Opt. 2015 Apr;20(4):46013. doi: 10.1117/1.JBO.20.4.046013.

Abstract

We present multimodal noncontact photoacoustic (PA) and optical coherence tomography (OCT) imaging. PA signals are acquired remotely on the surface of a specimen with a Mach-Zehnder interferometer. The interferometer is realized in a fiber-optic network using a fiber laser at 1550 nm as the source. In the same fiber-optic network, a spectral-domain OCT system is implemented. The OCT system utilizes a supercontinuum light source at 1310 nm and a spectrometer with an InGaAs line array detector. Light from the fiber laser and the OCT source is multiplexed into one fiber using a wavelength-division multiplexer; the same objective is used for both imaging modalities. Reflected light is spectrally demultiplexed and guided to the respective imaging systems. We demonstrate two-dimensional and three-dimensional imaging on a tissue-mimicking sample and a chicken skin phantom. The same fiber network and same optical components are used for PA and OCT imaging, and the obtained images are intrinsically coregistered.

摘要

我们展示了多模态非接触光声(PA)和光学相干断层扫描(OCT)成像。使用马赫-曾德尔干涉仪在样本表面远程采集PA信号。该干涉仪在光纤网络中实现,使用1550 nm的光纤激光器作为光源。在同一光纤网络中,实现了一个光谱域OCT系统。该OCT系统利用1310 nm的超连续光源和一个带有InGaAs线阵探测器的光谱仪。来自光纤激光器和OCT光源的光通过波分复用器复用进一根光纤;两种成像模态使用相同的物镜。反射光进行光谱解复用并导向各自的成像系统。我们在仿组织样本和鸡皮模型上展示了二维和三维成像。PA和OCT成像使用相同的光纤网络和相同的光学组件,并且所获得的图像在本质上是配准的。

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