a Hypertension in Africa Research Team (HART), North-West University , Potchefstroom , South Africa .
b Centre of Excellence for Nutrition (CEN), North-West University , Potchefstroom , South Africa , and.
Clin Exp Hypertens. 2015;37(6):511-7. doi: 10.3109/10641963.2015.1013123. Epub 2015 Apr 28.
Haemostatic- and oxidative stress markers are associated with increased cardiovascular risk. In the black population, evidence exists that both an imbalance in the haemostatic system and oxidative stress link with the development of hypertension. However, it is unclear whether these two risk components function independently or are related, specifically in the black population, who is known to have a high prevalence of stroke. We aimed to investigate associations between the haemostatic system and oxidative stress in black and white South Africans. We performed a cross-sectional study including 181 black (mean age, 44; 51.4% women) and 209 white (mean age, 45; 51.7% women) teachers. Several markers of the haemostatic- (von Willebrand factor, fibrinogen, plasminogen activator inhibitor-1, d-dimer and clot lysis time) and oxidant-antioxidant (serum peroxides, total glutathione, glutathione peroxidase- and glutathione reductase activities) systems were measured. Along with a worsened cardiovascular profile, the black group had higher haemostatic-, inflammation- and oxidative stress markers as well as decreased glutathione peroxidase activity. In multiple regression analyses, fibrinogen was positively associated with serum peroxides (p < 0.001) in both ethnic groups. In the black population, we found negative associations of von Willebrand factor and clot lysis time with glutathione peroxidase activity (p ≤ 0.008), while a positive association existed between clot lysis time and serum peroxides (p = 0.011) in the white population. We conclude that in the black population, decreased GPx activity accompanies an altered haemostatic profile, while in the white population associations may suggest that serum peroxides impair fibrin clot lysis.
止血和氧化应激标志物与心血管风险增加有关。在黑人人群中，有证据表明，止血系统的失衡和氧化应激都与高血压的发展有关。然而，目前尚不清楚这两个风险因素是否独立发挥作用，或者是否存在关联，特别是在黑人中，众所周知，他们中风的发病率很高。我们旨在研究黑人和南非白人的止血系统和氧化应激之间的关系。我们进行了一项横断面研究，包括 181 名黑人（平均年龄 44 岁；51.4%为女性）和 209 名白人（平均年龄 45 岁；51.7%为女性）教师。测量了止血系统（血管性血友病因子、纤维蛋白原、纤溶酶原激活物抑制剂-1、D-二聚体和血栓溶解时间）和氧化剂-抗氧化剂系统（血清过氧化物、总谷胱甘肽、谷胱甘肽过氧化物酶和谷胱甘肽还原酶活性）的几个标志物。与心血管状况恶化相关的是，黑人组的止血、炎症和氧化应激标志物水平更高，谷胱甘肽过氧化物酶活性更低。在多元回归分析中，纤维蛋白原与两组的血清过氧化物呈正相关（p < 0.001）。在黑人中，我们发现血管性血友病因子和血栓溶解时间与谷胱甘肽过氧化物酶活性呈负相关（p ≤ 0.008），而在白人中，血栓溶解时间与血清过氧化物呈正相关（p = 0.011）。我们的结论是，在黑人中，谷胱甘肽过氧化物酶活性降低伴随着止血系统的改变，而在白人中，可能表明血清过氧化物会损害纤维蛋白凝块的溶解。
