日本慢性肾小球肾炎患者的补体C6和C7基因多态性

Complement C6 and C7 polymorphisms in Japanese patients with chronic glomerulonephritis.

作者信息

Nishimukai H, Nakanishi I, Takeuchi Y, Sumiyoshi R, Mizutani K, Iida N, Shinomiya T

机构信息

Department of Legal Medicine, School of Medicine, Ehime University, Japan.

出版信息

Hum Hered. 1989;39(3):150-5. doi: 10.1159/000153851.

DOI:10.1159/000153851

PMID:2591978

Abstract

C6 and C7 types were studied in 158 Japanese patients with different types of chronic glomerulonephritis: 75 patients with IgA nephropathy (IgA-N); 49 patients with idiopathic membranous nephropathy (IMN), and 34 patients with minimal-change nephrotic syndrome (MCNS). There were significant differences in the C6 and C7 allele and phenotype frequencies between the patient groups and controls. A strong association was found between IgA-N and C7 5 phenotype (p less than 0.001, RR = 12.71), and between MCNS and C7 5 phenotype (p less than 0.001, RR = 14.20). A significant association between MCNS and C6 B2 phenotype (p less than 0.05, RR = 2.42) was also found. In the IMN patient group, a significant association with C7 4 phenotype (p less than 0.05, RR = 2.42) was observed. Thus, C6 and C7 phenotypes may be causative factors in the development of chronic glomerulonephritis.

摘要

对158例患有不同类型慢性肾小球肾炎的日本患者进行了C6和C7类型的研究：75例IgA肾病（IgA-N）患者；49例特发性膜性肾病（IMN）患者，以及34例微小病变肾病综合征（MCNS）患者。患者组与对照组之间的C6和C7等位基因及表型频率存在显著差异。发现IgA-N与C7 5表型之间存在强关联（p<0.001，RR = 12.71），以及MCNS与C7 5表型之间存在强关联（p<0.001，RR = 14.20）。还发现MCNS与C6 B2表型之间存在显著关联（p<0.05，RR = 2.42）。在IMN患者组中，观察到与C7 4表型存在显著关联（p<0.05，RR = 2.42）。因此，C6和C7表型可能是慢性肾小球肾炎发病的致病因素。