合成阿维菌素的进展。2. 11-表阿维菌素 I 右片段的对映选择性和非对映选择性合成。
Synthetic Progress toward Azadirachtins. 2. Enantio- and Diastereoselective Synthesis of the Right-Wing Fragment of 11-epi-Azadirachtin I.
机构信息
†Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
‡Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS) and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
出版信息
Org Lett. 2015 May 15;17(10):2338-41. doi: 10.1021/acs.orglett.5b00831. Epub 2015 Apr 28.
A stereoselective three-component coupling reaction of allylzinc bromide, silyl glyoxylate, and a β-lactone has been developed. This has been successfully applied to the enantio- and diastereoselective synthesis of the fully functionalized furopyran moiety of azadirachtins.
烯丙基溴化锌、硅基乙二醛酸酯和β-内酰胺的立体选择性三组分偶联反应已经被开发出来。该反应已经成功地应用于印苦素类化合物全官能化呋喃吡喃部分的对映选择性和非对映选择性合成。
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