猪血中的零 T 细胞不是自然杀伤细胞。
The null T cell in pig blood is not an NK cell.
作者信息
Duncan I A, Binns R M, Duffus W P
机构信息
Department of Clinical Veterinary Medicine, University of Cambridge, U.K.
出版信息
Immunology. 1989 Nov;68(3):392-5.
Up to 50% of the blood lymphocytes in young pigs are thymus-derived, lack all subset-specific markers and appear immunologically unresponsive, with no known functional role. In an examination of their possible role in natural killing, NK activity was found in unpurified mononuclear cells and in preparations of unselected and nylon non-adherent lymphocytes (T cells and Null cells). However, NK activity was abolished by removing the E rosette forming T cells using a rat IgM anti-pig CD2 monoclonal antibody and rabbit complement, but not by control treatments with a non-binding rat IgM monoclonal reagent and complement or with any other reagent alone. Thus the resting Null T cell appears not to play a significant role in natural killing.
幼猪体内高达50%的血液淋巴细胞源自胸腺，缺乏所有亚群特异性标志物，似乎无免疫反应性，其功能尚不明确。在一项关于它们在自然杀伤中可能作用的研究中，未纯化的单核细胞以及未分选和尼龙非黏附淋巴细胞（T细胞和空细胞）制剂中均发现了NK活性。然而，使用大鼠IgM抗猪CD2单克隆抗体和兔补体去除E花环形成T细胞后，NK活性消失，但用非结合性大鼠IgM单克隆试剂和补体或单独使用任何其他试剂进行对照处理时，NK活性并未消失。因此，静息空T细胞似乎在自然杀伤中不发挥重要作用。
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