Wolski Hubert, Bogacz Anna, Bartkowiak-Wieczorek Joanna, Greber Agnieszka, Pieńkowski Wojciech, Drews Krzysztof, Klejewski Andrzej, Seremak-Mrozikiewicz Agnieszka
Ginekol Pol. 2015 Mar;86(3):203-9. doi: 10.17772/gp/2006.
Osteoporosis is a chronic, generalized bone disease conditioned by many factors among which the genetic background plays the significant role. Bone morphogenetic protein (BMP2), a growth factor belong to su- perfamily of TNF- proteins, is actively involved in bone tissue metabolism. BMP2 protein shows the osteoinduction potential and regulates growth of cartilage plate, and the same directly influences the process of osteogenesis.
The aim of study was to examine the frequency of genotypes and alleles of 570A>T and 5375G>A of BMP2 gene polymorphisms in population of Polish postmenopausal women, as well as to analyze the relationship between investigated polymorphic variants and bone turnover parameters.
Into the study 117 postmenopausal women, Caucasian race (average age 55,1 years) living in Wielkopolska region were classified. The analysis of 570A>T and 5375G>A BMP2 polymorphisms was performed by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) while bone mineral density (BMD) was measured by DEXA method. In the research the chosen clinical and bone turnover parameters were analysed.
In both 570A>T and 5375G>A BMP2 polymorphisms the similar frequency of genotypes and alleles in investigated groups of postmenopausal women with osteoporosis, osteopenia and in the group with correct T-score were noted. The analysis do not show the relationship of clinical and bone turnover parameters with particular genotypes of BMP2 polymorphisms in women with osteoporosis, osteopenia and in the group with correct T-score.
The research did not confirm directly relationship of 570A>T and 5375G>A BMP2 polymorphisms with osteoporosis development in population of Polish postmenopausal women. The investigation also shows lack of correlation of 570A>T and 5375G>A BMP2 polymorphisms polymorphisms with analysed clinical and bone turnover parameters.
骨质疏松症是一种由多种因素引起的慢性全身性骨骼疾病，其中遗传背景起着重要作用。骨形态发生蛋白（BMP2）是一种属于肿瘤坏死因子蛋白超家族的生长因子，积极参与骨组织代谢。BMP2蛋白具有骨诱导潜力，可调节软骨板生长，并直接影响骨生成过程。
本研究旨在检测波兰绝经后女性群体中BMP2基因多态性570A>T和5375G>A的基因型和等位基因频率，并分析所研究的多态性变体与骨转换参数之间的关系。
本研究纳入了117名居住在大波兰地区的绝经后白种女性（平均年龄55.1岁）。采用聚合酶链反应/限制性片段长度多态性（PCR/RFLP）方法分析BMP2基因570A>T和5375G>A多态性，采用双能X线吸收法（DEXA）测量骨密度（BMD）。研究中分析了选定的临床和骨转换参数。
在570A>T和5375G>A这两种BMP2基因多态性中，在患有骨质疏松症、骨量减少的绝经后女性研究组以及T值正常的组中，观察到基因型和等位基因频率相似。分析未显示骨质疏松症、骨量减少的女性以及T值正常组中临床和骨转换参数与BMP2基因多态性的特定基因型之间存在关联。
该研究未直接证实波兰绝经后女性群体中BMP2基因多态性570A>T和5375G>A与骨质疏松症发生之间的关系。该调查还表明，570A>T和5375G>A这两种BMP2基因多态性与所分析的临床和骨转换参数之间缺乏相关性。
