Martikainen Mika H, Rönnemaa Tapani, Majamaa Kari
Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland
Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Diab Vasc Dis Res. 2015 Jul;12(4):302-4. doi: 10.1177/1479164115579007. Epub 2015 Apr 28.
We investigated whether mitochondrial (mtDNA) haplogroups and maternal family history of diabetes mellitus were associated with vascular diabetes mellitus complications in a population-based cohort of 299 Finnish diabetes mellitus patients with disease onset in young adult age. We found that haplogroup U was more prevalent among patients with no vascular diabetes mellitus complications than among those with at least one complication (p = 0.038). Haplogroup U was also more prevalent among the patients who reported maternal family history of diabetes mellitus than among those who did not (p = 0.0013). Furthermore, haplogroup U was more prevalent among patients with maternal family history of diabetes mellitus but no vascular diabetes mellitus complications than among those with at least one vascular diabetes mellitus complication but no maternal family history of diabetes mellitus (p = 0.0003 for difference). These findings suggest that different mtDNA-related factors may influence the risk of diabetes mellitus per se and the risk of vascular diabetes mellitus complications. Further studies are, however, warranted to replicate and elaborate on these results.
我们在一个以人群为基础的队列中，对299名成年早期发病的芬兰糖尿病患者进行了研究，以探讨线粒体（mtDNA）单倍群和糖尿病家族史是否与糖尿病血管并发症有关。我们发现，在无糖尿病血管并发症的患者中，单倍群U比至少有一种并发症的患者更为普遍（p = 0.038）。在报告有糖尿病家族史的患者中，单倍群U也比没有家族史的患者更为普遍（p = 0.0013）。此外，在有糖尿病家族史但无糖尿病血管并发症的患者中，单倍群U比至少有一种糖尿病血管并发症但无糖尿病家族史的患者更为普遍（差异p = 0.0003）。这些发现表明，不同的线粒体DNA相关因素可能会影响糖尿病本身的风险以及糖尿病血管并发症的风险。然而，需要进一步的研究来重复和详细阐述这些结果。
