Unitat d'Antropologia Biològica, Department BABVE, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
Dirección General de Salud Pública, Consejería de Sanidad, Junta de Castilla y León, 47007 Valladolid, Spain.
Mitochondrion. 2019 Jan;44:1-6. doi: 10.1016/j.mito.2017.12.004. Epub 2017 Dec 16.
There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p=0.001; OR=2.379, 95% CI [1.440-3.990]). Otherwise, our data also suggest a beneficial role of haplogroup J against hypertension (p=0.019; OR=0.348, 95% CI [0.144-0.840]). These results may provide some guidance for predicting the genetic risk of these diseases in different human populations through the differences in energy efficiency between haplogroups.
有强有力的证据表明，常见的线粒体 DNA（mtDNA）单倍群可能影响心血管疾病（CVDs）的发病机制。在这项匹配的病例对照研究中，我们研究了 mtDNA 单倍群与两种 CVD，即心肌梗死（MI）和中风，以及经典心血管危险因素之间的关联。获得的数据表明，单倍群 H 构成 MI 的易感性风险因素（p=0.001；OR=2.379，95%CI[1.440-3.990]）。另一方面，我们的数据还表明单倍群 J 对高血压具有有益作用（p=0.019；OR=0.348，95%CI[0.144-0.840]）。这些结果可能通过单倍群之间能量效率的差异，为预测不同人群中这些疾病的遗传风险提供一些指导。
