Huang C, Tomata Y, Kakizaki M, Sugawara Y, Hozawa A, Momma H, Tsuji I, Nagatomi R
Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering, 980-8575 Sendai, Japan.
Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 980-8575 Sendai, Japan.
Nutr Metab Cardiovasc Dis. 2015 Jun;25(6):594-601. doi: 10.1016/j.numecd.2015.03.010. Epub 2015 Mar 27.
Population-based researches indicate that circulating adiponectin is inversely associated with muscle strength. However, interpretation of the findings has been limited by the use of a cross-sectional design. This study aimed to examine the prospective relationship between baseline circulating adiponectin concentration and change in muscular function-related physical performance in older adults.
A 1-year prospective cohort study of Japanese community-dwelling elderly was conducted between 2002 and 2003. Four hundred thirty-four older persons participated in the measurements of physical function, including leg extension power, functional reach, timed up-and-go test, and 10-m maximum walking speed, at baseline and follow-up. After adjustment for potential covariates, higher serum adiponectin concentration was found to be significantly associated with poorer physical performance at baseline (leg extension power [watt], P < 0.001; functional reach [cm], P < 0.001; log timed up-and-go test, P = 0.007; log 10-m maximum walking speed, P < 0.001). The results of the prospective analysis by analysis of covariance indicated that the elderly with higher serum adiponectin concentrations (tertiles) at baseline tended to have a decreased performance in leg extension power (means [95% confidence interval]: lowest, -105 [-125, -85.7]; middle, -117 [-135, -97.8]; highest, -140 [-160, -120], watt, P for trend = 0.021) and timed up-and-go test (lowest, -0.08 [-0.28, -0.12]; middle, -0.10 [-0.29, 0.10]; highest, 0.28 [0.07, 0.48], s, P for trend = 0.019), but not two other functioning.
High circulating adiponectin concentration may be an indicator of decreased physical performance, especially muscle strength, in older adults.
基于人群的研究表明，循环脂联素与肌肉力量呈负相关。然而，这些研究结果的解读因采用横断面设计而受到限制。本研究旨在探讨老年人基线循环脂联素浓度与肌肉功能相关身体表现变化之间的前瞻性关系。
2002年至2003年期间，对日本社区居住的老年人进行了为期1年的前瞻性队列研究。434名老年人参与了基线和随访时的身体功能测量，包括腿部伸展力量、功能性伸展距离、计时起立行走测试和10米最大步行速度。在对潜在协变量进行调整后，发现较高的血清脂联素浓度与基线时较差的身体表现显著相关（腿部伸展力量[瓦特]，P<0.001；功能性伸展距离[厘米]，P<0.001；计时起立行走测试对数，P = 0.007；10米最大步行速度对数，P<0.001）。协方差分析的前瞻性分析结果表明，基线时血清脂联素浓度较高（三分位数）的老年人腿部伸展力量（均值[95%置信区间]：最低，-105[-125，-85.7]；中间，-117[-135，-97.8]；最高，-140[-160，-120]，瓦特，趋势P = 0.021）和计时起立行走测试（最低，-0.08[-0.28，-0.12]；中间，-0.10[-0.29，0.10]；最高，0.28[0.07，0.48]，秒，趋势P = 0.019）的表现往往会下降，但其他两项功能则不然。
高循环脂联素浓度可能是老年人身体表现下降，尤其是肌肉力量下降的一个指标。
Zotero 插件