Tylutka Anna, Morawin Barbara, Torz Natalia, Osmólska Joanna, Łuszczki Kacper, Jarmużek Paweł, Zembron-Lacny Agnieszka
Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 28 Zyty Str, Zielona Gora, 65-417, Poland.
Student Research Group, University of Zielona Gora, Collegium Medicum University of Zielona Gora, 28 Zyty Str, Zielona Gora, 65-417, Poland.
Immun Ageing. 2024 Sep 28;21(1):64. doi: 10.1186/s12979-024-00468-7.
An active lifestyle is of key importance for reduction of obesity and inflammation, as well as circulating levels of adipokines. Therefore, the aim of our study was to assess the relationship of physical fitness with chronic inflammatory status, and to evaluate biomarkers useful in the analysis of adipose tissue dysfunction. Sixty-three older adults (69.6 ± 5.1 years) were allocated to a high n = 31 (women n = 23 and men n = 8 male) or low physical fitness n = 32 (women n = 29 and men n = 3) group based on gait speed values (1.4-1.8 m/s or ≤ 1.3 m/s). The gait speed correlated with hand grip strength (r = 0.493, p = 0.0001) and with leptin level (R = -0.372, p = 0.003), which shows the benefits of physical activity on muscle strength and circulating adipokines. In low physical fitness group, 58.1% individuals had adiponectin to leptin ratio (Adpn/Lep) < 0.5 revealing dysfunction of adipose tissue and high cardiometabolic risk; 20% of the group were obese with BMI ≥ 30 kg/m. In high physical fitness group, 25.8% of individuals had Adpn/Lep ≥ 1.0 i.e., within the reference range. Markers of systemic inflammation were significantly related to physical fitness: CRP/gait speed (r = -0.377) and HMGB-1/gait speed (r = -0.264). The results of the ROC analysis for Adpn (AUC = 0.526), Lep (AUC = 0.745) and HMGB-1 (AUC = 0.689) indicated their diagnostic potential for clinical prognosis in older patients. The optimal threshold values corresponded to 1.2 μg/mL for Adpn (sensitivity 74.2%, specificity 41.9%, OR = 1.4, 95%Cl 0.488-3.902), 6.7 ng/mL for Lep (sensitivity 56.2%, specificity 93.5%, OR = 14.8, 95%Cl 3.574-112.229), 2.63 mg/L for CRP (sensitivity 51.6%, specificity 84.3%, OR = 4.4, 95% Cl 1.401- 16.063) and 34.2 ng/mL for HMGB-1 (sensitivity 62.0%, specificity 86.6%, OR = 12.0, 95%Cl 3.254-61.614). The highest sensitivity and specificity were observed for Leptin and HMGB-1. The study revealed changes in inflammatory status in older adults at various levels of physical fitness and demonstrated diagnostic usefulness of adipokines in the assessment of adipose tissue inflammation.
积极的生活方式对于降低肥胖、炎症以及脂肪因子的循环水平至关重要。因此，我们研究的目的是评估身体素质与慢性炎症状态之间的关系，并评估有助于分析脂肪组织功能障碍的生物标志物。根据步速值（1.4 - 1.8米/秒或≤1.3米/秒），将63名老年人（69.6±5.1岁）分为高身体素质组（n = 31，女性n = 23，男性n = 8）或低身体素质组（n = 32，女性n = 29，男性n = 3）。步速与握力（r = 0.493，p = 0.0001）以及瘦素水平（R = -0.372，p = 0.003）相关，这表明体育活动对肌肉力量和循环脂肪因子有益。在低身体素质组中，58.1%的个体脂联素与瘦素比值（Adpn/Lep）<0.5，表明脂肪组织功能障碍且心血管代谢风险高；该组20%的个体肥胖，BMI≥30kg/m²。在高身体素质组中，25.8%的个体Adpn/Lep≥1.0，即处于参考范围内。全身炎症标志物与身体素质显著相关：CRP/步速（r = -0.377）和HMGB - 1/步速（r = -0.264）。对Adpn（AUC = 0.526）、Lep（AUC = 0.745）和HMGB - 1（AUC = 0.689）的ROC分析结果表明它们对老年患者临床预后具有诊断潜力。最佳阈值分别为：Adpn为1.2μg/mL（敏感性74.2%，特异性41.9%，OR = 1.4，95%Cl 0.488 - 3.902），Lep为6.7ng/mL（敏感性56.2%，特异性93.5%，OR = 14.8，95%Cl 3.574 - 112.229），CRP为2.63mg/L（敏感性51.6%，特异性84.3%，OR = 4.4，95%Cl 1.401 - 16.063），HMGB - 1为34.2ng/mL（敏感性62.0%，特异性86.6%，OR = 12.0，95%Cl 3.254 - 61.614）。瘦素和HMGB - 1的敏感性和特异性最高。该研究揭示了不同身体素质水平的老年人炎症状态的变化，并证明了脂肪因子在评估脂肪组织炎症方面的诊断用途。
