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老年人血浆 ZAG 与脂联素的相关性:性别修饰和虚弱特异性。

Correlation between plasma ZAG and adiponectin in older adults: gender modification and frailty specificity.

机构信息

Division of Family Medicine, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan.

Department of Family Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.

出版信息

BMC Geriatr. 2021 Jul 27;21(1):442. doi: 10.1186/s12877-021-02379-4.

Abstract

BACKGROUND

Adiponectin and zinc alpha2-glycoprotein (ZAG) are associated with frailty. This study aims to further examine the association of adiponectin with ZAG.

METHODS

Outpatients aged 65 years or older with chronic disease followed up in a hospital-based program were recruited for a comprehensive geriatric assessment. We excluded outpatients who were bedridden, residing in a nursing home, with expected life expectancy less than 6 months, or with severe hearing or communication impairment. Plasma ZAG and adiponectin levels were measured. Association between plasma ZAG and adiponectin levels was analyzed by univariate and multivariable linear regression analyses.

RESULTS

A total of 189 older adults were enrolled (91 men and 98 women, mean age: 77.2 ± 6.1 years). Log-transformed plasma ZAG level was 1.82 ± 0.11 μg/mL, and it was significantly higher in men than that in women (1.85 ± 0.12 vs 1.79 ± 0.10 μg/mL, P = .0006). Log-transformed plasma adiponectin level was 1.00 ± 0.26 μg/mL, and there was no significant gender difference (P = .195). Overall, plasma ZAG level positively correlated with plasma adiponectin level in the multivariable linear regression analysis (P = .0085). The gender-specific significance, however, was less clear: this relationship was significant in men (P = .0049) but not in women (P = .2072). To be more specific by frailty phenotype components, plasma adiponectin was positively correlated with weight loss (P = .0454) and weakness (P = .0451).

CONCLUSIONS

Both of ZAG and adiponectin may be potential frailty biomarkers. Plasma ZAG is an independent factor of plasma adiponectin, especially in older male adults.

摘要

背景

脂联素和锌-α2-糖蛋白(ZAG)与虚弱有关。本研究旨在进一步探讨脂联素与 ZAG 的关系。

方法

我们招募了在医院为基础的项目中接受慢性病治疗的年龄在 65 岁或以上的门诊患者进行全面老年评估。我们排除了卧床不起、居住在养老院、预期寿命少于 6 个月或有严重听力或沟通障碍的门诊患者。测量了血浆 ZAG 和脂联素水平。通过单变量和多变量线性回归分析来分析血浆 ZAG 和脂联素水平之间的关系。

结果

共纳入 189 名老年人(91 名男性和 98 名女性,平均年龄:77.2±6.1 岁)。对数转换后的血浆 ZAG 水平为 1.82±0.11μg/mL,男性显著高于女性(1.85±0.12 比 1.79±0.10μg/mL,P=0.0006)。对数转换后的血浆脂联素水平为 1.00±0.26μg/mL,男女之间无显著差异(P=0.195)。总体而言,在多变量线性回归分析中,血浆 ZAG 水平与血浆脂联素水平呈正相关(P=0.0085)。然而,这种关系在性别特异性上并不明显:这种关系在男性中具有统计学意义(P=0.0049),但在女性中没有统计学意义(P=0.2072)。更具体地说,根据虚弱表型成分,血浆脂联素与体重减轻(P=0.0454)和虚弱(P=0.0451)呈正相关。

结论

ZAG 和脂联素都可能是潜在的虚弱生物标志物。血浆 ZAG 是血浆脂联素的一个独立因素,特别是在老年男性中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/857d/8314466/069902c78432/12877_2021_2379_Fig1_HTML.jpg

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