地中海饮食能抵消腹部肥胖的不良影响吗？
Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?
作者信息
Eguaras S, Toledo E, Buil-Cosiales P, Salas-Salvadó J, Corella D, Gutierrez-Bedmar M, Santos-Lozano J M, Arós F, Fiol M, Fitó M, Ros E, Serra-Majem L, Pintó X, Martínez J A, Sorlí J V, Muñoz M A, Basora J, Estruch R, Martínez-González M Á
机构信息
Servicio Navarro de Salud-Osasunbidea, Pamplona, Navarra, Spain; Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Navarra, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Navarra, Spain; PREDIMED Research Network (RD 06/0045), Instituto de Salud Carlos III, Madrid, Spain; Centro Investigación Biomédica Red Obesidad-Nutrición (CIBERobn), Madrid, Spain.
出版信息
Nutr Metab Cardiovasc Dis. 2015 Jun;25(6):569-74. doi: 10.1016/j.numecd.2015.03.001. Epub 2015 Mar 11.
BACKGROUND AND AIM
We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health.
METHODS AND RESULTS
We assessed the relationship between baseline waist-to-height ratio (WHtR) and major cardiovascular events during a median follow-up of 4.8 years in the Prevention with Mediterranean Diet (PREDIMED) randomized primary prevention trial, which tested a MeDiet against a control diet (advice on a low-fat diet). We also examined whether the MeDiet intervention was able to counteract the detrimental cardiovascular effects of an increased WHtR. The trial included 7447 participants (55-80 years old, 57% women) at high cardiovascular risk but free of cardiovascular disease (CVD) at enrollment. An increased risk of CVD events (myocardial infarction, stroke, or cardiovascular death) was apparent for the highest versus the lowest quartile of WHtR (multivariable-adjusted hazard ratio: 1.98) (95% confidence interval: 1.10-3.57; linear trend: p = 0.019) only in the control-diet group, but not in the two groups allocated to intervention with MeDiet (p for interaction = 0.034). This apparent interaction suggesting that the intervention counterbalanced the detrimental cardiovascular effects of adiposity was also significant for body mass index (BMI) (p = 0.01) and waist circumference (p = 0.043).
CONCLUSIONS
The MeDiet may counteract the harmful effects of increased adiposity on the risk of CVD.
背景与目的
我们检验了如下假设，即采用地中海饮食（MeDiet）进行干预可减轻腹部肥胖对心血管健康的众所周知的有害影响。
方法与结果
在“地中海饮食预防（PREDIMED）”随机初级预防试验中，我们评估了基线腰高比（WHtR）与主要心血管事件之间的关系，该试验对MeDiet与对照饮食（低脂饮食建议）进行了测试，中位随访时间为4.8年。我们还研究了MeDiet干预是否能够抵消WHtR升高对心血管的有害影响。该试验纳入了7447名心血管疾病高风险参与者（年龄55 - 80岁，57%为女性），这些参与者在入组时无心血管疾病（CVD）。仅在对照饮食组中，WHtR最高四分位数与最低四分位数相比，CVD事件（心肌梗死、中风或心血管死亡）风险增加明显（多变量调整风险比：1.98）（95%置信区间：1.10 - 3.57；线性趋势：p = 0.019），而在分配接受MeDiet干预的两组中未出现这种情况（交互作用p = 0.034）。这种表明干预抵消了肥胖对心血管有害影响的明显交互作用在体重指数（BMI）方面也很显著（p = 0.01），在腰围方面同样显著（p = 0.043）。
结论
MeDiet可能抵消肥胖增加对CVD风险的有害影响。
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