Beavers Daniel P, Pettinger Mary, Espeland Mark A, Snively Beverly M, Leng Xiaoyan, Hunt Julie R, Tindle Hilary A, Shumaker Sally A
Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
J Gerontol A Biol Sci Med Sci. 2016 Mar;71 Suppl 1(Suppl 1):S13-22. doi: 10.1093/gerona/glv050. Epub 2015 Apr 28.
The Women's Health Initiative has collected data on the aging process of postmenopausal women for over two decades, including data on many women who have achieved age 80 years and older. However, there has not been any previous effort to characterize the 80+ cohort and to identify associated retention factors.
We include all women at baseline of the Women's Health Initiative who would be at least 80 years of age as of September 17, 2012. We summarize retention rates during the study and across two re-enrollment campaigns as well as the demographic and health-related characteristics that predicted retention. Further, we describe the longitudinal change from baseline in the women identified as members of the 80+ cohort.
Retention rates were lower during each of two re-enrollment periods (74% and 83% retained during re-enrollment periods 1 and 2, respectively) than during the first and second data collection periods (90% each). Women who were retained were more likely to be white, educated, and healthier at baseline. Women age 80 and older saw modest changes in body mass index and depression burden, despite lower physical activity and increased cardiovascular disease.
The characteristics of women who were retained in the 80+ cohort differ in significant ways compared with their peers at baseline. Identifying the characteristics associated with attrition in older cohorts is important because aging and worsening health has a negative impact on study attrition. Strategies should be implemented to improve retention rates among less healthy older adults.
妇女健康倡议组织已经收集绝经后女性衰老过程的数据超过二十年，包括许多已达80岁及以上女性的数据。然而，此前尚未有任何研究对80岁及以上人群进行特征描述并确定相关的留存因素。
我们纳入了妇女健康倡议组织基线时截至2012年9月17日至少80岁的所有女性。我们总结了研究期间以及两次重新入组活动期间的留存率，以及预测留存的人口统计学和健康相关特征。此外，我们描述了被确定为80岁及以上队列成员的女性从基线开始的纵向变化。
在两个重新入组期间，留存率均低于首次和第二次数据收集期间（每次均为90%）（重新入组期间1和2的留存率分别为74%和83%）。被留存的女性在基线时更可能是白人、受过教育且健康状况更好。80岁及以上的女性尽管身体活动减少且心血管疾病增加，但体重指数和抑郁负担仍有适度变化。
80岁及以上队列中被留存女性的特征与其基线时的同龄人相比有显著差异。确定老年队列中与失访相关的特征很重要，因为衰老和健康状况恶化对研究失访有负面影响。应实施策略以提高健康状况较差的老年人的留存率。
