Mersmann H J
U.S. Department of Agriculture Clay Center, NE 68933.
J Anim Sci. 1989 Nov;67(11):2913-20. doi: 10.2527/jas1989.67112913x.
Previous results indicate that clenbuterol decreases carcass adipose tissue accretion when administered to pigs but does not appear to stimulate the adipose tissue beta-adrenergic receptor. Clenbuterol increases plasma free fatty acid concentration when acutely infused in vivo, suggesting an indirect affect. One possible indirect effect is that clenbuterol could change blood flow to adipose tissue. Blood flow was measured with radiolabeled microspheres in tissues from pigs before and after infusion of a beta-adrenergic agonist for 30 min. High probability levels (up to P less than .2) were used to indicate trends due to extreme variability. Infusion of isoproterenol increased heart rate, plasma free fatty acid concentration and blood flow at many adipose tissue sites and at a few skeletal muscle sites. Infusion of isoproterenol decreased blood pressure. Infusion of clenbuterol increased heart rate and tended to increase blood flow to several skin and adipose tissue sites slightly. The results suggest that increased adipose tissue blood flow may contribute to the accelerated release of free fatty acids when clenbuterol is infused acutely in vivo.
先前的研究结果表明，给猪使用克伦特罗可减少胴体脂肪组织的蓄积，但似乎不会刺激脂肪组织的β-肾上腺素能受体。当在体内急性输注克伦特罗时，其会增加血浆游离脂肪酸浓度，提示存在间接作用。一种可能的间接作用是，克伦特罗可能会改变流向脂肪组织的血流量。在输注β-肾上腺素能激动剂30分钟前后，用放射性标记微球测量猪组织中的血流量。由于变异性极大，故采用高概率水平（高达P<0.2）来表明趋势。输注异丙肾上腺素可增加心率、血浆游离脂肪酸浓度，并增加许多脂肪组织部位以及少数骨骼肌部位的血流量。输注异丙肾上腺素会降低血压。输注克伦特罗可增加心率，并倾向于使流向几个皮肤和脂肪组织部位的血流量略有增加。结果表明，当在体内急性输注克伦特罗时，脂肪组织血流量增加可能有助于游离脂肪酸的加速释放。
