Zhang Shuai-nan, Li Xu-zhao, Liu Shu-min, Lu Fang
Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, P. R. China.
Planta Med. 2015 Jun;81(9):722-32. doi: 10.1055/s-0035-1545915. Epub 2015 Apr 29.
Acanthopanax senticosus is extensively used to treat various nervous and cerebrovascular diseases in traditional medicinal systems in China and Russia. Ultrahigh-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry coupled with pattern recognition methods was used to investigate the effects of A. senticosus on the peripheral system in rats. The analysis of possible pathways influenced by A. senticosus was performed with MetaboAnalyst and Cytoscape software. After treatment with A. senticosus, 21 modulated metabolites in heart tissue, 20 in liver tissue, 14 in spleen tissue, 17 in lung tissue, 16 in kidney tissue, and 12 in a serum sample were identified and considered potential biomarkers of A. senticosus treatments. The regulation of some endogenous metabolites by A. senticosus could be beneficial for the treatment of several peripheral system diseases, such as hypertension, cancer, and oxidative stress, etc. However, there were also some upregulated endogenous metabolites producing potential toxicity to the peripheral system. A metabonomic analysis revealed that protection and toxicity coexisted in the effects of A. senticosus on the peripheral system, which may be a practical guide for its safe use and beneficial to the expansion of its application.
刺五加在中国和俄罗斯的传统医学体系中被广泛用于治疗各种神经和脑血管疾病。采用超高效液相色谱-四极杆飞行时间质谱联用模式识别方法，研究刺五加对大鼠外周系统的影响。使用MetaboAnalyst和Cytoscape软件对受刺五加影响的可能途径进行分析。用刺五加处理后，在心脏组织中鉴定出21种调节代谢物，肝脏组织中20种，脾脏组织中14种，肺组织中17种，肾脏组织中16种，血清样本中12种，并将其视为刺五加治疗的潜在生物标志物。刺五加对一些内源性代谢物的调节可能有助于治疗几种外周系统疾病，如高血压、癌症和氧化应激等。然而，也有一些上调的内源性代谢物对外周系统产生潜在毒性。代谢组学分析表明，刺五加对外周系统的影响中保护作用和毒性并存，这可能为其安全使用提供实际指导，并有利于其应用范围的扩大。
