Lu Fang, Yang Xiao-dan, Jing Yue-e, Zhang Na, Liu Shu-min
Zhong Yao Cai. 2015 May;38(5):1004-8.
Using metabolomics method to study the influence of Acanthopanax senticosus polysaccharides on cardiac endogenous metabolism in rats, in order to find potential biomarkers and analyze the metabolic pathways which can explore the pharmacological effects and mechanisms of action.
20 SD rats were randomly divided into two groups, the blank and Acanthopanax senticosus polysaccharides treatment groups, which were treated with saline and Acanthopanax senticosus polysaccharide for 20 days. On the 21th day,heart tissue were collected and each sample extract was analyzed by UPLC-Q-TOF/MS.
20 potential biomarkers and 6 major metabolic pathways related to cardiovascular and cerebrovascular diseases were identified.
Acanthopanax senticosus polysaccharides has a certain pharmacological effects on cardio-cerebro vascular diseases, cancer and other diseases. Its mechanism may be related to the metabolic process of amino acids, fatty acid and folate.
采用代谢组学方法研究刺五加多糖对大鼠心脏内源性代谢的影响，以寻找潜在生物标志物并分析代谢途径，从而探究其药理作用及作用机制。
将20只SD大鼠随机分为两组，即空白组和刺五加多糖治疗组，分别给予生理盐水和刺五加多糖处理20天。在第21天，采集心脏组织，每个样品提取物通过超高效液相色谱-四极杆飞行时间串联质谱仪（UPLC-Q-TOF/MS）进行分析。
鉴定出20种潜在生物标志物以及6条与心脑血管疾病相关的主要代谢途径。
刺五加多糖对心脑血管疾病、癌症等疾病具有一定的药理作用。其作用机制可能与氨基酸、脂肪酸和叶酸的代谢过程有关。
