Hussnain Syed Amal, Alsberge Joseph B, Ehrlich Joshua R, Shimmyo Mitsugu, Radcliffe Nathan M
Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA.
Department of Ophthalmology, New York Medical College, Valhalla, NY, USA.
Acta Ophthalmol. 2015 Dec;93(8):e627-30. doi: 10.1111/aos.12726. Epub 2015 Apr 28.
Corneal hysteresis (CH) is lower in glaucomatous eyes. The aim of this study was to determine and compare the change in CH over time between normal, open angle glaucoma (POAG) and diabetic subjects.
We retrospectively analysed records of patients undergoing assessment with the Ocular Response Analyzer (Reichert, Corp., New York, NY, USA). Right eyes with at least 7 measurements were included. Patients with ocular pathology other than POAG were excluded. Two-sample t-tests, chi-squared and logistic regression were used to analyse data.
A total of 1418 normal and 322 POAG patients were included. Patients with POAG were significantly older (70.73 ± 11.33 vs. 61.59 ± 16.56 years; p < 0.001), had a longer follow-up (4.14 ± 1.34 vs. 2.72 ± 1.49 years; p < 0.001) and had lower CH (9.58 ± 2.17 vs. 9.95 ± 2.19 mmHg p = 0.01), but there were no gender differences between groups (61.5 vs. 57.7% female; p = 0.21). We observed a significantly greater decrease in CH among patients with POAG (-0.11 ± 0.73 vs. 0.07 ± 2.31 mm Hg/year; p = 0.02). The relation between ∆CH/year and diagnosis persisted after adjusting for age and follow-up time (OR 0.90; 95% CI 0.82, 0.99; p = 0.03). We found CH to be higher in diabetics vs. non-diabetics (10.34 ± 2.04 vs. 9.88 ± 2.19; p = 0.02), but ∆CH/year was not different (0.07 ± 1.27 vs. 0.03 ± 2.10; p = 0.77).
Patients with POAG in this study had a significantly greater rate of CH decline compared to normal. There was no significant difference in rate of CH change in diabetic and non-diabetic patients.
青光眼患者的角膜滞后（CH）较低。本研究的目的是确定并比较正常、开角型青光眼（POAG）和糖尿病患者CH随时间的变化。
我们回顾性分析了使用眼反应分析仪（美国纽约州赖歇特公司）进行评估的患者记录。纳入至少有7次测量值的右眼。排除患有POAG以外眼部疾病的患者。使用双样本t检验、卡方检验和逻辑回归分析数据。
共纳入1418例正常患者和322例POAG患者。POAG患者年龄显著更大（70.73±11.33岁 vs. 61.59±16.56岁；p<0.001），随访时间更长（4.14±1.34年 vs. 2.72±1.49年；p<0.001），CH更低（9.58±2.17 mmHg vs. 9.95±2.19 mmHg，p=0.01），但两组间性别无差异（女性分别为61.5%和57.7%；p=0.21）。我们观察到POAG患者的CH下降幅度显著更大（-0.11±0.73 vs. 0.07±2.31 mmHg/年；p=0.02）。在校正年龄和随访时间后，每年CH变化量与诊断之间的关系仍然存在（OR 0.90；95% CI 0.82，0.99；p=0.03）。我们发现糖尿病患者的CH高于非糖尿病患者（10.34±2.04 vs. 9.88±2.19；p=0.02），但每年CH变化量无差异（0.07±1.27 vs. 0.03±2.10；p=0.77）。
本研究中，POAG患者的CH下降速率显著高于正常患者。糖尿病患者和非糖尿病患者的CH变化速率无显著差异。
