Johnson Jennifer, Borres Magnus P, Nordvall Lennart, Lidholm Jonas, Janson Christer, Alving Kjell, Malinovschi Andrei
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Thermo Fisher Scientific, Uppsala, Sweden.
PLoS One. 2015 Apr 29;10(4):e0124675. doi: 10.1371/journal.pone.0124675. eCollection 2015.
The relationship between perceived food hypersensitivity in asthmatics, food allergen sensitization, asthma control and asthma-related quality of life has not been studied.
Our aim was to study the prevalence of perceived food hypersensitivity in a cohort of young asthmatics, its relation to food allergen sensitization, and any correlation to asthma control and asthma-related quality of life.
Perceived food hypersensitivity, as well as IgE sensitization to common food allergens, levels of exhaled nitric oxide (FeNO), and blood eosinophil counts (B-Eos) were assessed in 408 subjects (211 women) with asthma, aged (mean ± SEM) 20.4 ± 0.3 years. Subjects filled out the Asthma Control Test (ACT) and the Mini Asthma Quality of Life Questionnaire (Mini-AQLQ). Inflammation was assessed by means of FeNO and B-Eos.
Fifty-three per cent of subjects reported food hypersensitivity. A corresponding food allergen sensitization was found in 68% of these subjects. Non-atopic subjects with perceived food hypersensitivity (n = 31) had lower ACT (19 (15 - 22) vs. 21 (20 - 23), p < 0.001) and Mini-AQLQ -scores (5.3 (4.3 - 6.1) vs. 6.1 (5.5 - 6.5), p < 0.001) than subjects with no food hypersensitivity (n = 190), despite lower levels of FeNO and B-Eos (p < 0.05).
Food hypersensitivity was commonly reported among young asthmatics. In a majority of cases, a corresponding food allergen sensitization was found. A novel and clinically important finding was that non-atopic subjects with perceived food hypersensitivity were characterized by poorer asthma control and asthma-related quality of life.
哮喘患者中感知到的食物超敏反应、食物过敏原致敏、哮喘控制及哮喘相关生活质量之间的关系尚未得到研究。
我们的目的是研究一组年轻哮喘患者中感知到的食物超敏反应的患病率、其与食物过敏原致敏的关系，以及与哮喘控制和哮喘相关生活质量的任何相关性。
对408名哮喘患者（211名女性）进行了评估，这些患者年龄（均值±标准误）为20.4±0.3岁，评估内容包括感知到的食物超敏反应、对常见食物过敏原的IgE致敏、呼出一氧化氮（FeNO）水平和血液嗜酸性粒细胞计数（B-Eos）。受试者填写哮喘控制测试（ACT）和哮喘生活质量简易问卷（Mini-AQLQ）。通过FeNO和B-Eos评估炎症。
53%的受试者报告有食物超敏反应。在这些受试者中，68%发现有相应的食物过敏原致敏。与无食物超敏反应的受试者（n = 190）相比，有感知到食物超敏反应的非特应性受试者（n = 31）的ACT得分（19（15 - 22）对21（20 - 23），p < 0.001）和Mini-AQLQ得分（5.3（4.3 - 6.1）对6.1（5.5 - 6.5），p < 0.001）更低，尽管其FeNO和B-Eos水平较低（p < 0.05）。
年轻哮喘患者中普遍报告有食物超敏反应。在大多数情况下，发现有相应的食物过敏原致敏。一个新的且具有临床重要性的发现是，有感知到食物超敏反应的非特应性受试者的特点是哮喘控制和哮喘相关生活质量较差。
