Xeuatvongsa Anonh, Mirza Sara, Winter Christian, Feldon Keith, Vongphrachanh Phengta, Phonekeo Darouny, Denny Justin, Khanthamaly Viengphone, Kounnavong Bounheuang, Lylianou Doualy, Phousavath Sisouphane, Norasingh Sisouveth, Boutta Nao, Olsen Sonja, Bresee Joseph, Moen Ann, Corwin Andrew
National Immunization Program, Ministry of Health, Vientiane, Lao People's Democratic Republic (Lao PDR).
Influenza Division, United States Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
PLoS One. 2015 Apr 29;10(4):e0121717. doi: 10.1371/journal.pone.0121717. eCollection 2015.
The Lao PDR, as did most countries of the Mekong Region, embarked on a pandemic vaccine initiative to counter the threat posed by influenza A(H1N1)pdm09. Overall, estimated vaccine coverage of the Lao population was 14%, with uptake in targeted health care workers and pregnant women 99% and 41%, respectively. Adverse Events Following Immunization accounted for only 6% of survey driven, reported vaccination experiences, with no severe consequences or deaths. Public acceptability of the vaccine campaign was high (98%). Challenges to vaccine deployment included: 1) no previous experience in fielding a seasonal influenza vaccine, 2) safety and efficacy concerns, and 3) late arrival of vaccine 10 months into the pandemic. The Lao success in surmounting these hurdles was in large measure attributed to the oversight assigned the National Immunization Program, and national sensitivities in responding to the avian influenza A(H5N1) crisis in the years leading up to the pandemic. The Lao "lessons learned" from pandemic vaccine deployment are made even more relevant four years on, given the many avian influenza strains circulating in the region, all with pandemic potential.
老挝人民民主共和国与湄公河地区的大多数国家一样，发起了一项大流行疫苗倡议，以应对甲型H1N1流感大流行带来的威胁。总体而言，老挝人口的疫苗接种估计覆盖率为14%，目标医护人员和孕妇的接种率分别为99%和41%。免疫接种后不良事件仅占调查驱动的报告疫苗接种经历的6%，没有严重后果或死亡情况。疫苗接种活动的公众接受度很高（98%）。疫苗部署面临的挑战包括：1）此前没有季节性流感疫苗接种经验，2）对安全性和有效性的担忧，以及3）在大流行开始10个月后疫苗才姗姗来迟。老挝成功克服这些障碍在很大程度上归功于国家免疫规划的监督，以及在大流行前几年对甲型H5N1禽流感危机作出反应时的国家敏感性。鉴于该地区有许多具有大流行潜力的禽流感毒株在传播，老挝从大流行疫苗部署中“吸取的经验教训”在四年后的今天显得更加重要。
