Reilly Gayatri, Melamud Alexander, Lipscomb Peter, Toussaint Brian
*Department of Ophthalmology, Washington Hospital Center, Washington, DC; †The Retina Group of Washington, Washington, DC; and ‡Georgetown University, Washington, DC.
Retina. 2015 Sep;35(9):1817-21. doi: 10.1097/IAE.0000000000000558.
To evaluate whether patients with macular pucker (epiretinal membrane [ERM]) and good preoperative visual acuity (20/50 or better) benefit from small-gauge pars plana vitrectomy with membrane peeling.
Retrospective chart review of eyes undergoing small-gauge pars plana vitrectomy for ERM. Inclusion criterion was impaired visual acuity (20/50 or better) due to ERM. Exclusion criteria were preoperative visual acuity of 20/60 or worse, previous surgery (other than uncomplicated cataract surgery), and any documented evidence of macular or corneal disease that would limit visual potential. The main outcome measure was final visual acuity. Secondary outcomes included the role of internal limiting membrane peeling, and the effect of preoperative cystoid macular edema and internal limiting membrane peeling on visual acuity.
One hundred and forty eyes met inclusion criteria of which 94% underwent 25-gauge vitrectomy (remainder had 23-gauge). There was a statistically significant improvement in final vision with the mean preoperative visual acuity of 0.305 logMAR (20/40) and 1-year visual acuity of 0.250 logMAR (20/35) (P = 0.0167). Cataract formation in phakic patients had a significant effect on the final visual outcome. Fifty-six of 63 patients (89%) in the phakic cohort developed a visually significant cataract by study end. The mean time to recommendation of cataract surgery was 8.4 months. Thirty-eight eyes (27%) had preoperative cystoid macular edema. Fifty-nine eyes (42%) underwent internal limiting membrane peeling. Neither one of these secondary outcome measures had a significant effect on the final visual outcome.
Pars plana vitrectomy is both efficacious and safe an option for patients with ERMs and good preoperative vision. Eyes with an ERM and vision 20/50 or better had a statistically significant improvement in the final visual outcome after small-gauge pars plana vitrectomy surgery. As with large-gauge vitrectomy, cataract formation occurred in most phakic eyes within the first year after surgery.
评估黄斑皱襞(视网膜前膜[ERM])且术前视力良好(20/50或更佳)的患者是否能从采用膜剥除术的小切口玻璃体切割术中获益。
对接受小切口玻璃体切割术治疗ERM的眼睛进行回顾性病历审查。纳入标准为因ERM导致视力受损(20/50或更佳)。排除标准为术前视力20/60或更差、既往手术史(不包括单纯性白内障手术)以及任何记录在案的会限制视力潜能的黄斑或角膜疾病证据。主要观察指标为最终视力。次要观察指标包括内界膜剥除的作用,以及术前黄斑囊样水肿和内界膜剥除对视力的影响。
140只眼睛符合纳入标准,其中94%接受了25G玻璃体切割术(其余接受23G)。最终视力有统计学意义的改善,术前平均视力为0.305 logMAR(20/40),1年时视力为0.250 logMAR(20/35)(P = 0.0167)。有晶状体眼患者的白内障形成对最终视力结果有显著影响。在有晶状体眼队列中,63例患者中有56例(89%)在研究结束时出现了有临床意义的白内障。推荐白内障手术的平均时间为8.4个月。38只眼睛(27%)有术前黄斑囊样水肿。59只眼睛(42%)接受了内界膜剥除。这些次要观察指标均对最终视力结果无显著影响。
对于ERM且术前视力良好的患者,玻璃体切割术是一种有效且安全的选择。ERM且视力20/50或更佳的眼睛在小切口玻璃体切割术后最终视力结果有统计学意义的改善。与大切口玻璃体切割术一样,大多数有晶状体眼在术后第一年内发生白内障。