Eliassen Carl Fredrik, Selnes Per, Selseth Almdahl Ina, Reinvang Ivar, Fladby Tormod, Hessen Erik
Department of Psychology, University of Oslo, Oslo, Norway.
Dement Geriatr Cogn Disord. 2015;40(1-2):44-53. doi: 10.1159/000381142. Epub 2015 Apr 25.
BACKGROUND/AIMS: To investigate differences in hippocampal (HP) subfields and the adjoining perirhinal and entorhinal cortices (PRC and ERC) between amnestic mild cognitive impairment (aMCI) and multi-domain amnestic MCI (mdMCI) patients, and controls.
Nineteen patients characterized as aMCI were compared with 24 mdMCI patients and 31 controls by means of an automatic HP segmentation procedure.
We found significant atrophy of the PRC and ERC in aMCI relative to controls, whereas a more pronounced pattern of atrophy in most subfields, including total HP volume, was found in the mdMCI group. The mdMCI group also had a significant cornu ammonis sector 4 region with dentate gyrus, subiculum and total HP atrophy relative to aMCI.
The aMCI group showed atrophy in the PRC and ERC, whereas significantly more affection of the HP subfields was evident in mdMCI. The mdMCI group may thus represent clinical progression relative to aMCI coupled with HP subfield affection.
背景/目的：研究遗忘型轻度认知障碍（aMCI）和多领域遗忘型MCI（mdMCI）患者及对照组之间海马体（HP）亚区以及相邻的鼻周皮质和内嗅皮质（PRC和ERC）的差异。
通过自动HP分割程序，将19例确诊为aMCI的患者与24例mdMCI患者及31例对照组进行比较。
我们发现，相对于对照组，aMCI患者的PRC和ERC有明显萎缩，而mdMCI组在包括总HP体积在内的大多数亚区出现了更明显的萎缩模式。相对于aMCI组，mdMCI组的海马角4区、齿状回、下托和总HP也有明显萎缩。
aMCI组的PRC和ERC出现萎缩，而mdMCI组的HP亚区受影响更为明显。因此，mdMCI组可能代表相对于aMCI的临床进展以及HP亚区受影响的情况。
