Reddy Sujan C, Jacob Jesse T, Varkey Jay B, Gaynes Robert P
Division of Infectious Diseases, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303, USA.
Expert Rev Anti Infect Ther. 2015 Jul;13(7):843-54. doi: 10.1586/14787210.2015.1040766. Epub 2015 Apr 30.
A majority of patients hospitalized in the US hospitals receive an antibiotic during their hospitalization. Furthermore, up to half of antibiotics prescribed in hospitals are inappropriate. In the setting of continued emergence of antibiotic-resistant pathogens and a limited pipeline of new antimicrobials, attention to optimizing antibiotic use in healthcare settings is essential. We review the measures of antibiotic consumption in the USA, the evolving metrics for comparing antibiotic use (known as benchmarking), trends in antibiotic use, the structure and outcome measures of Antimicrobial Stewardship Programs and interventions to optimize antimicrobial use.
在美国医院住院的大多数患者在住院期间都会接受抗生素治疗。此外，医院开出的抗生素中多达一半是不恰当的。在抗生素耐药病原体持续出现且新型抗菌药物研发渠道有限的情况下，关注优化医疗机构抗生素使用至关重要。我们回顾了美国抗生素消费的衡量标准、用于比较抗生素使用情况的不断演变的指标（称为基准化）、抗生素使用趋势、抗菌药物管理计划的结构和结果指标以及优化抗菌药物使用的干预措施。
